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10.1158/2159-8290.CD-14-0157 http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-14-0157 C4184920!4184920 !25100205     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25100205 &cmd=llinks): Failed to open stream: HTTP request failed! 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ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents |pdf=|usr=}}{{25100205 }} gab.com Text ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents JO: Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=25100205 #FOAvip Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving normal cells unharmed, increasing therapeutic response while minimizing toxicity. Using an siRNA screen targeting over 240 DNA damage response genes, we identified novel sensitizers to alkylating agents. In particular, the base excision repair (BER) pathway, including 3-methylpurine-DNA glycosylase (MPG), as well as ataxia telangiectasia mutated (ATM), were identified in our screen. Interestingly, we identified MPG as a direct novel substrate of ATM. ATM-mediated phosphorylation of MPG was required for enhanced MPG function. Importantly, combined inhibition or loss of MPG and ATM resulted in increased alkylating agent-induced cytotoxicity in vitro and prolonged survival in vivo. The discovery of the ATM-MPG axis will lead to improved treatment of alkylating agent-resistant tumors. SIGNIFICANCE: Inhibition of ATM and MPG-mediated BER cooperate to sensitize tumor cells to alkylating agents, impairing tumor growth in vitro and in vivo with no toxicity to normal cells, providing an ideal therapeutic window. Twit Text FOAVip ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents ????Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=25100205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25100205 #FOAvip English Wikipedia <ref>{{Cite pmid|25100205 }}</ref> ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents #MMPMID25100205 Agnihotri S ; Burrell K ; Buczkowicz P ; Remke M ; Golbourn B ; Chornenkyy Y ; Gajadhar A ; Fernandez NA ; Clarke ID ; Barszczyk MS ; Pajovic S ; Ternamian C ; Head R ; Sabha N ; Sobol RW ; Taylor MD ; Rutka JT ; Jones C ; Dirks PB ; Zadeh G ; Hawkins C Cancer Discov 2014[Oct]; 4 (10 ): 1198-213 PMID25100205 show ga Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving normal cells unharmed, increasing therapeutic response while minimizing toxicity. Using an siRNA screen targeting over 240 DNA damage response genes, we identified novel sensitizers to alkylating agents. In particular, the base excision repair (BER) pathway, including 3-methylpurine-DNA glycosylase (MPG), as well as ataxia telangiectasia mutated (ATM), were identified in our screen. Interestingly, we identified MPG as a direct novel substrate of ATM. ATM-mediated phosphorylation of MPG was required for enhanced MPG function. Importantly, combined inhibition or loss of MPG and ATM resulted in increased alkylating agent-induced cytotoxicity in vitro and prolonged survival in vivo. The discovery of the ATM-MPG axis will lead to improved treatment of alkylating agent-resistant tumors. SIGNIFICANCE: Inhibition of ATM and MPG-mediated BER cooperate to sensitize tumor cells to alkylating agents, impairing tumor growth in vitro and in vivo with no toxicity to normal cells, providing an ideal therapeutic window. |*Drug Resistance, Neoplasm/genetics [MESH] |Age Factors [MESH] |Animals [MESH] |Antineoplastic Agents, Alkylating/*pharmacology [MESH] |Ataxia Telangiectasia Mutated Proteins/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cluster Analysis [MESH] |DNA Copy Number Variations [MESH] |DNA Glycosylases/*metabolism [MESH] |DNA Repair [MESH] |Dacarbazine/analogs & derivatives/pharmacology [MESH] |Disease Models, Animal [MESH] |Enzyme Activation [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glioblastoma/drug therapy/genetics/metabolism/mortality/pathology [MESH] |Humans [MESH] |Models, Biological [MESH] |Phosphorylation [MESH] |RNA Interference [MESH] |RNA, Small Interfering/genetics [MESH] |Temozolomide [MESH]ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic (epmc).pdf DeepDyve Pubget Overpricing