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10.1158/0008-5472.CAN-14-1203 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-1203 C4184887!4184887!25038230     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (18): 5079-90 Nephropedia Template TP {{tp|p=25038230|t=2014. Natural Killer Cells Eradicate Galectin-1 Deficient Glioma in the Absence of Adaptive Immunity |pdf=|usr=}}{{25038230}} gab.com Text Natural Killer Cells Eradicate Galectin-1 Deficient Glioma in the Absence of Adaptive Immunity JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25038230 #FOAvip Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance. However, the immune escape mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain unclear. Here we show that malignant glioma cells suppress NK immune surveillance by overexpressing the ?-galactoside-binding lectin galectin-1. Conversely, galectin-1 deficient glioma cells could be eradicated by host NK cells prior to the initiation of an anti-tumor T-cell response. In vitro experiments demonstrated that galectin-1 deficient GL26-Cit glioma cells are ~3-fold more sensitive to NK-mediated tumor lysis that galectin-1 expressing cells. Our findings suggest that galectin-1 suppression in human glioma could improve patient survival by restoring NK immune surveillance that can eradicate glioma cells. Twit Text FOAVip Natural Killer Cells Eradicate Galectin-1 Deficient Glioma in the Absence of Adaptive Immunity ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25038230 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25038230 #FOAvip English Wikipedia <ref>{{Cite pmid|25038230}}</ref> Natural Killer Cells Eradicate Galectin-1 Deficient Glioma in the Absence of Adaptive Immunity #MMPMID25038230 Baker GJ; Chockley P; Yadav VN; Doherty R; Ritt M; Sivaramakrishnan S; Castro MG; Lowenstein PR Cancer Res 2014[Sep]; 74 (18): 5079-90 PMID25038230show ga Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance. However, the immune escape mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain unclear. Here we show that malignant glioma cells suppress NK immune surveillance by overexpressing the ?-galactoside-binding lectin galectin-1. Conversely, galectin-1 deficient glioma cells could be eradicated by host NK cells prior to the initiation of an anti-tumor T-cell response. In vitro experiments demonstrated that galectin-1 deficient GL26-Cit glioma cells are ~3-fold more sensitive to NK-mediated tumor lysis that galectin-1 expressing cells. Our findings suggest that galectin-1 suppression in human glioma could improve patient survival by restoring NK immune surveillance that can eradicate glioma cells. äNatural Killer Cells Eradicate Galectin-1 Deficient Glioma in the Abse(epmc).pdf DeepDyve Pubget Overpricing