Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25093496
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25093496
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Cancer
2014 ; 111
(7
): 1391-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph
nodes of colorectal cancer patients
#MMPMID25093496
Wu X
; Zhang H
; Xing Q
; Cui J
; Li J
; Li Y
; Tan Y
; Wang S
Br J Cancer
2014[Sep]; 111
(7
): 1391-9
PMID25093496
show ga
BACKGROUND: The blockade of PD-1-PD-L1 pathway is emerging as an effective
therapeutic strategy for several advanced cancers. But the immune regulatory role
of PD-1-PD-L1 pathway is not clear in colorectal cancer (CRC) patients. This
study aims to evaluate the role of PD-1-PD-L1 pathway in CD8(+) T-cell functions
in tumour-draining lymph nodes (TDLNs) and tumours of CRC patients. METHODS: PD-1
expression on CD8(+) T cells was examined by flow cytometry, and PD-L1 expression
in TDLNs and tumour tissues were examined by immunohistochemistry. Production of
IFN-?, IL-2 and expression of granzyme B, perforin in CD8(+) T cells were
detected by intracellular staining. RESULTS: PD-1 expression is markedly
upregulated on CD8(+) T cells in TDLNs and tumours compared with that in
peripheral blood. PD-1-expressing CD8(+) T cells are competent for production of
cytokine (IL-2 and IFN-?) and perforin in the tumour-free lymph nodes (TFLNs),
but exhibit exhausted phenotypes in tumours. In addition, PD-L1 is highly
expressed in tumours rather than TFLNs, which is closely correlated with the
impairment of IFN-? production of tumour-infiltrating PD-1(+) CD8(+) T cells.
CONCLUSIONS: Our findings suggest a suppressive effect of PD-1 on CD8(+) T-cell
function in tumours, but not in TFLNs.
free
free
free
