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10.1074/jbc.M114.586024

http://scihub22266oqcxt.onion/10.1074/jbc.M114.586024
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C4183815!4183815!25112872
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suck abstract from ncbi


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pmid25112872      J+Biol+Chem 2014 ; 289 (40): 27807-13
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  • Glutathionylation of the Aquaporin-2 Water Channel: A NOVEL POST-TRANSLATIONAL MODIFICATION MODULATED BY THE OXIDATIVE STRESS* #MMPMID25112872
  • Tamma G; Ranieri M; Di Mise A; Centrone M; Svelto M; Valenti G
  • J Biol Chem 2014[Oct]; 289 (40): 27807-13 PMID25112872show ga
  • Background: The trafficking of the vasopressin-dependent water channel AQP2 is regulated by post-translational modifications as phosphorylations and ubiquitylation.Results: AQP2 is subjected to S-glutathionylation, which is modulated by ROS production.Conclusion: AQP2 is sensitive to oxidative stress.Significance: Identifying this novel post-translational modification is crucial to understand renal diseases characterized by oxidative stress and AQP2-dependent water balance disturbance.
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