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10.1074/jbc.M114.569608

http://scihub22266oqcxt.onion/10.1074/jbc.M114.569608
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C4183782!4183782!25135640
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suck abstract from ncbi


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pmid25135640      J+Biol+Chem 2014 ; 289 (40): 27418-31
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  • Structural Maintenance of Chromosome (SMC) Proteins Link Microtubule Stability to Genome Integrity* #MMPMID25135640
  • Laflamme G; Tremblay-Boudreault T; Roy MA; Andersen P; Bonneil É; Atchia K; Thibault P; D'Amours D; Kwok BH
  • J Biol Chem 2014[Oct]; 289 (40): 27418-31 PMID25135640show ga
  • Background: SMC proteins organize chromosome architecture, whereas microtubules form the structural framework for chromosome movement in mitosis.Results: SMC proteins bind to and stabilize microtubules to promote proper mitotic spindle formation.Conclusion: SMC proteins can provide a functional link between microtubules and DNA to ensure faithful chromosome segregation.Significance: SMC-microtubule interactions are essential to establish a robust system for maintaining genome integrity.
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