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10.1002/adhm.201400103

http://scihub22266oqcxt.onion/10.1002/adhm.201400103
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C4182177!4182177!24692076
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suck abstract from ncbi


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pmid24692076      Adv+Healthc+Mater 2014 ; 3 (10): 1629-37
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  • Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy #MMPMID24692076
  • Shen J; Kim HC; Mu C; Gentile E; Mai J; Wolfram J; Ji Ln; Ferrari M; Mao Zw; Shen H
  • Adv Healthc Mater 2014[Oct]; 3 (10): 1629-37 PMID24692076show ga
  • Cancer is a complex disease that usually requires several treatment modalities. Here, we have designed a multifunctional nanotherapeutic system incorporating small interfering RNA (siRNA) and gold nanorods for photothermal therapy. Surface engineered gold nanorods with polyethylenimine were synthesized using a layer-by-layer assembly and siRNA was absorbed on the surface. The siRNA was efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells were then irradiated with near-infrared (NIR) light, causing heat-induced anticancer activity. The combination of gene silencing and photothermal therapy resulted in effective inhibition of cell proliferation.
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