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10.5966/sctm.2014-0090

http://scihub22266oqcxt.onion/10.5966/sctm.2014-0090
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C4181402!4181402!25122691
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suck abstract from ncbi


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pmid25122691      Stem+Cells+Transl+Med 2014 ; 3 (10): 1182-7
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  • Concise Review: Dedifferentiation Meets Cancer Development: Proof of Concept for Epigenetic Cancer #MMPMID25122691
  • Yamada Y; Haga H; Yamada Y
  • Stem Cells Transl Med 2014[Oct]; 3 (10): 1182-7 PMID25122691show ga
  • Using induced pluripotent stem cell technology to alter the epigenetic status of differentiated cells, a recent study revealed that some types of cancer can develop through disruption of the epigenetic status triggered by dedifferentiation. This review addresses the epigenetic mechanism associated with maintenance or conversion of cell identity and introduces the system responsible for in vivo reprogramming to demonstrate the involvement of dedifferentiation-driven epigenetic disruption in cancer development.
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