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10.1016/j.cell.2014.08.038 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.08.038 C4181352!4181352 !25259925     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25259925 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2014 ; 159 (1 ): 122-133 Nephropedia Template TP {{tp|p=25259925 |t=2014. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling |pdf=|usr=}}{{25259925 }} gab.com Text Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25259925 #FOAvip Mechanistic target of rapamycin complex 1 (mTORC1) integrates diverse environmental signals to control cellular growth and organismal homeostasis. In response to nutrients, Rag GTPases recruit mTORC1 to the lysosome to be activated, but how Rags are regulated remains incompletely understood. Here, we show that Sestrins bind to the heterodimeric RagA/B-RagC/D GTPases, and function as guanine nucleotide dissociation inhibitors (GDIs) for RagA/B. Sestrin overexpression inhibits amino-acid-induced Rag guanine nucleotide exchange and mTORC1 translocation to the lysosome. Mutation of the conserved GDI motif creates a dominant-negative form of Sestrin that renders mTORC1 activation insensitive to amino acid deprivation, whereas a cell-permeable peptide containing the GDI motif inhibits mTORC1 signaling. Mice deficient in all Sestrins exhibit reduced postnatal survival associated with defective mTORC1 inactivation in multiple organs during neonatal fasting. These findings reveal a nonredundant mechanism by which the Sestrin family of GDIs regulates the nutrient-sensing Rag GTPases to control mTORC1 signaling. Twit Text FOAVip Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25259925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25259925 #FOAvip English Wikipedia <ref>{{Cite pmid|25259925 }}</ref> Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling #MMPMID25259925 Peng M ; Yin N ; Li MO Cell 2014[Sep]; 159 (1 ): 122-133 PMID25259925 show ga Mechanistic target of rapamycin complex 1 (mTORC1) integrates diverse environmental signals to control cellular growth and organismal homeostasis. In response to nutrients, Rag GTPases recruit mTORC1 to the lysosome to be activated, but how Rags are regulated remains incompletely understood. Here, we show that Sestrins bind to the heterodimeric RagA/B-RagC/D GTPases, and function as guanine nucleotide dissociation inhibitors (GDIs) for RagA/B. Sestrin overexpression inhibits amino-acid-induced Rag guanine nucleotide exchange and mTORC1 translocation to the lysosome. Mutation of the conserved GDI motif creates a dominant-negative form of Sestrin that renders mTORC1 activation insensitive to amino acid deprivation, whereas a cell-permeable peptide containing the GDI motif inhibits mTORC1 signaling. Mice deficient in all Sestrins exhibit reduced postnatal survival associated with defective mTORC1 inactivation in multiple organs during neonatal fasting. These findings reveal a nonredundant mechanism by which the Sestrin family of GDIs regulates the nutrient-sensing Rag GTPases to control mTORC1 signaling. |*Signal Transduction [MESH] |AMP-Activated Protein Kinases/metabolism [MESH] |Amino Acid Sequence [MESH] |Amino Acids/metabolism [MESH] |Animals [MESH] |Animals, Newborn [MESH] |Cell Cycle Proteins/genetics/*metabolism [MESH] |Embryo, Mammalian/cytology [MESH] |Female [MESH] |Fibroblasts/metabolism [MESH] |Gene Knock-In Techniques [MESH] |Heat-Shock Proteins/genetics/*metabolism [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Molecular Sequence Data [MESH] |Monomeric GTP-Binding Proteins/genetics/metabolism [MESH] |Multiprotein Complexes/*metabolism [MESH] |Nuclear Proteins/genetics/*metabolism [MESH] |Peroxidases [MESH] |Pregnancy [MESH] |Sequence Alignment [MESH] |Starvation/metabolism [MESH] |TOR Serine-Threonine Kinases/*metabolism [MESH] |Tuberous Sclerosis Complex 2 Protein [MESH]Sestrins function as guanine nucleotide dissociation inhibitors for Ra(epmc).pdf DeepDyve Pubget Overpricing