Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25035283
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Genitourin+Cancer
2014 ; 12
(5
): 341-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Current practices in the management of adverse events associated with targeted
therapies for advanced renal cell carcinoma: a national survey of oncologists
#MMPMID25035283
Ruiz JN
; Belum VR
; Creel P
; Cohn A
; Ewer M
; Lacouture ME
Clin Genitourin Cancer
2014[Oct]; 12
(5
): 341-7
PMID25035283
show ga
BACKGROUND: Oncologists treating patients with targeted therapies encounter
adverse events (AEs) that pose management challenges, lead to dosing
inconsistencies, and impact patient quality of life. Oncologists' practices and
attitudes in the management of targeted therapy-related AEs in patients with
renal cell carcinoma (RCC) are poorly understood. We sought to identify unmet
needs associated with AE management and understand oncologists' treatment
optimization strategies. METHODS: A 24-item online survey was administered in
August 2012 to 119 US oncologists treating patients with advanced RCC. The survey
solicited responses regarding demographics, practice settings, AE management
practice patterns and beliefs, treatment barriers, and patient education.
RESULTS: Respondents indicated that between 25% and 50% of patients require dose
modification/discontinuation because of AEs. The greatest barrier to optimizing
treatment for RCC is the unpredictability of patient responses to treatment
(43%). Most respondents (78%) discuss AE management with patients, but only a
minority of them proactively reach out to patients (46%). Most practitioners
(70%) refer patients to nononcology specialists when faced with unfamiliar AEs,
although finding interested physicians (43%) and time constraints (40%) were the
most commonly cited barriers to consulting with other specialties. CONCLUSION:
Results suggest that many patients require dose modification/discontinuation
because of AEs and that nononcologists are a frequently utilized resource to
manage these events. There is a need for predictive drug toxicity markers to
establish counseling and prevention, along with opportunities for increased
education on supportive care techniques to maintain health-related quality of
life and consistent dosing.
|Antineoplastic Agents/administration & dosage/*adverse effects/therapeutic use
[MESH]
|Carcinoma, Renal Cell/*drug therapy
[MESH]
|Disease Management
[MESH]
|Drug-Related Side Effects and Adverse Reactions/*therapy
[MESH]