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10.1523/JNEUROSCI.2848-14.2014 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.2848-14.2014 C4180470!4180470 !25274811     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25274811 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neurosci 2014 ; 34 (40 ): 13314-25 Nephropedia Template TP {{tp|p=25274811 |t=2014. The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons |pdf=|usr=}}{{25274811 }} gab.com Text The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25274811 #FOAvip Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis. Here we reveal that the APP plays an important role in the neural progenitor proliferation and newborn neuron maturation in the mouse dentate gyrus. APP controls adult neurogenesis through a non cell-autonomous mechanism by GABAergic neurons, as selective deletion of GABAergic, but not glutamatergic, APP disrupts adult hippocampal neurogenesis. APP, highly expressed in the majority of GABAergic neurons in the dentate gyrus, enhances the inhibitory tone to granule cells. By regulating both tonic and phasic GABAergic inputs to dentate granule cells, APP maintains excitatory-inhibitory balance and preserves cognitive functions. Our studies uncover an indispensable role of APP in the GABAergic system for controlling adult hippocampal neurogenesis, and our findings indicate that APP dysfunction may contribute to impaired neurogenesis and cognitive decline associated with AD. Twit Text FOAVip The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25274811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25274811 #FOAvip English Wikipedia <ref>{{Cite pmid|25274811 }}</ref> The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons #MMPMID25274811 Wang B ; Wang Z ; Sun L ; Yang L ; Li H ; Cole AL ; Rodriguez-Rivera J ; Lu HC ; Zheng H J Neurosci 2014[Oct]; 34 (40 ): 13314-25 PMID25274811 show ga Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis. Here we reveal that the APP plays an important role in the neural progenitor proliferation and newborn neuron maturation in the mouse dentate gyrus. APP controls adult neurogenesis through a non cell-autonomous mechanism by GABAergic neurons, as selective deletion of GABAergic, but not glutamatergic, APP disrupts adult hippocampal neurogenesis. APP, highly expressed in the majority of GABAergic neurons in the dentate gyrus, enhances the inhibitory tone to granule cells. By regulating both tonic and phasic GABAergic inputs to dentate granule cells, APP maintains excitatory-inhibitory balance and preserves cognitive functions. Our studies uncover an indispensable role of APP in the GABAergic system for controlling adult hippocampal neurogenesis, and our findings indicate that APP dysfunction may contribute to impaired neurogenesis and cognitive decline associated with AD. |Age Factors [MESH] |Amyloid beta-Protein Precursor/genetics/*metabolism [MESH] |Animals [MESH] |Basic Helix-Loop-Helix Transcription Factors/deficiency [MESH] |Cells, Cultured [MESH] |Excitatory Amino Acid Antagonists/pharmacology [MESH] |Female [MESH] |GABAergic Neurons/*physiology [MESH] |Hippocampus/*cytology [MESH] |Interneurons/*physiology [MESH] |Male [MESH] |Membrane Potentials/drug effects/genetics [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Nerve Tissue Proteins/deficiency [MESH] |Nestin/genetics/metabolism [MESH] |Neurogenesis/genetics/*physiology [MESH] |Sodium Channel Blockers/pharmacology [MESH] |Synaptic Transmission/genetics [MESH] |Tetrodotoxin/pharmacology [MESH]The amyloid precursor protein controls adult hippocampal neurogenesis (epmc).pdf DeepDyve Pubget Overpricing