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10.1016/j.cell.2014.08.028 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.08.028 C4180118!4180118 !25219674     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25219674 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA |pdf=|usr=}}{{25219674 }} gab.com Text Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25219674 #FOAvip Pseudouridine is the most abundant RNA modification, yet except for a few well-studied cases, little is known about the modified positions and their function(s). Here, we develop ?-seq for transcriptome-wide quantitative mapping of pseudouridine. We validate ?-seq with spike-ins and de novo identification of previously reported positions and discover hundreds of unique sites in human and yeast mRNAs and snoRNAs. Perturbing pseudouridine synthases (PUS) uncovers which pseudouridine synthase modifies each site and their target sequence features. mRNA pseudouridinylation depends on both site-specific and snoRNA-guided pseudouridine synthases. Upon heat shock in yeast, Pus7p-mediated pseudouridylation is induced at >200 sites, and PUS7 deletion decreases the levels of otherwise pseudouridylated mRNA, suggesting a role in enhancing transcript stability. rRNA pseudouridine stoichiometries are conserved but reduced in cells from dyskeratosis congenita patients, where the PUS DKC1 is mutated. Our work identifies an enhanced, transcriptome-wide scope for pseudouridine and methods to dissect its underlying mechanisms and function. Twit Text FOAVip Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25219674 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25219674 #FOAvip English Wikipedia <ref>{{Cite pmid|25219674 }}</ref> Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA #MMPMID25219674 Schwartz S ; Bernstein DA ; Mumbach MR ; Jovanovic M ; Herbst RH ; León-Ricardo BX ; Engreitz JM ; Guttman M ; Satija R ; Lander ES ; Fink G ; Regev A Cell 2014[Sep]; 159 (1 ): 148-162 PMID25219674 show ga Pseudouridine is the most abundant RNA modification, yet except for a few well-studied cases, little is known about the modified positions and their function(s). Here, we develop ?-seq for transcriptome-wide quantitative mapping of pseudouridine. We validate ?-seq with spike-ins and de novo identification of previously reported positions and discover hundreds of unique sites in human and yeast mRNAs and snoRNAs. Perturbing pseudouridine synthases (PUS) uncovers which pseudouridine synthase modifies each site and their target sequence features. mRNA pseudouridinylation depends on both site-specific and snoRNA-guided pseudouridine synthases. Upon heat shock in yeast, Pus7p-mediated pseudouridylation is induced at >200 sites, and PUS7 deletion decreases the levels of otherwise pseudouridylated mRNA, suggesting a role in enhancing transcript stability. rRNA pseudouridine stoichiometries are conserved but reduced in cells from dyskeratosis congenita patients, where the PUS DKC1 is mutated. Our work identifies an enhanced, transcriptome-wide scope for pseudouridine and methods to dissect its underlying mechanisms and function. |Animals [MESH] |Candida albicans/genetics/metabolism [MESH] |Cell Cycle Proteins/genetics/metabolism [MESH] |Dyskeratosis Congenita/genetics/metabolism [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Intramolecular Transferases/chemistry/metabolism [MESH] |Mice [MESH] |Molecular Sequence Data [MESH] |Nuclear Proteins/genetics/metabolism [MESH] |Pseudouridine/*analysis/metabolism [MESH] |RNA, Messenger/*chemistry [MESH] |RNA, Ribosomal/chemistry/genetics [MESH] |RNA, Untranslated/*chemistry [MESH] |RNA/chemistry/genetics [MESH] |Saccharomyces cerevisiae Proteins/chemistry/metabolism [MESH] |Saccharomyces cerevisiae/genetics/metabolism [MESH] |Substrate Specificity [MESH]Transcriptome-wide mapping reveals widespread dynamic-regulated pseudo(epmc).pdf DeepDyve Pubget Overpricing