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10.4161/rna.29305 http://scihub22266oqcxt.onion/10.4161/rna.29305 C4179958!4179958!24921245     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA+Biol 2014 ; 11 (7): 836-44 Nephropedia Template TP {{tp|p=24921245|t=2014. Sorting signal targeting mRNA into hepatic extracellular vesicles |pdf=|usr=}}{{24921245}} gab.com Text Sorting signal targeting mRNA into hepatic extracellular vesicles JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=24921245 #FOAvip Intercellular communication mediated by extracellular vesicles has proved to play an important role in normal and pathological scenarios. However not too much information about the sorting mechanisms involved in loading the vesicles is available. Recently, our group has characterized the mRNA content of vesicles released by hepatic cellular systems, showing that a set of transcripts was particularly enriched in the vesicles in comparison with their intracellular abundance. In the current work, based on in silico bioinformatics tools, we have mapped a novel sequence of 12 nucleotides C[TA]G[GC][AGT]G[CT]C[AT]GG[GA], which is significantly enriched in the set of mRNAs that accumulate in extracellular vesicles. By including a 3?-UTR containing this sequence in a luciferase mRNA reporter, we have shown that in a hepatic cellular system this reporter mRNA was incorporated into extracellular vesicles. This study identifies a sorting signal in mRNAs that is involved in their enrichment in EVs, within a hepatic non-tumoral cellular model. Twit Text FOAVip Sorting signal targeting mRNA into hepatic extracellular vesicles ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=24921245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24921245 #FOAvip English Wikipedia <ref>{{Cite pmid|24921245}}</ref> Sorting signal targeting mRNA into hepatic extracellular vesicles #MMPMID24921245 Szostak N; Royo F; Rybarczyk A; Szachniuk M; Blazewicz J; del Sol A; Falcon-Perez JM RNA Biol 2014[Jul]; 11 (7): 836-44 PMID24921245show ga Intercellular communication mediated by extracellular vesicles has proved to play an important role in normal and pathological scenarios. However not too much information about the sorting mechanisms involved in loading the vesicles is available. Recently, our group has characterized the mRNA content of vesicles released by hepatic cellular systems, showing that a set of transcripts was particularly enriched in the vesicles in comparison with their intracellular abundance. In the current work, based on in silico bioinformatics tools, we have mapped a novel sequence of 12 nucleotides C[TA]G[GC][AGT]G[CT]C[AT]GG[GA], which is significantly enriched in the set of mRNAs that accumulate in extracellular vesicles. By including a 3?-UTR containing this sequence in a luciferase mRNA reporter, we have shown that in a hepatic cellular system this reporter mRNA was incorporated into extracellular vesicles. This study identifies a sorting signal in mRNAs that is involved in their enrichment in EVs, within a hepatic non-tumoral cellular model. äSorting signal targeting mRNA into hepatic extracellular vesicles (epmc).pdf DeepDyve Pubget Overpricing