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10.1208/s12249-014-0141-8

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suck abstract from ncbi


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pmid24895077
      AAPS+PharmSciTech 2014 ; 15 (5 ): 1263-74
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  • Vancomycin-eluting niosomes: a new approach to the inhibition of staphylococcal biofilm on abiotic surfaces #MMPMID24895077
  • Barakat HS ; Kassem MA ; El-Khordagui LK ; Khalafallah NM
  • AAPS PharmSciTech 2014[Oct]; 15 (5 ): 1263-74 PMID24895077 show ga
  • A new vancomycin (VCM)-eluting mixed bilayer niosome formulation was evaluated for the control of staphylococcal colonization and biofilm formation on abiotic surfaces, a niosome application not explored to date. Cosurfactant niosomes were prepared using a Span 60/Tween 40/cholesterol blend (1: 1: 2). Tween 40, a polyethoxylated amphiphile, was included to enhance VCM entrapment and confer niosomal surface properties precluding bacterial adhesion. VCM-eluting niosomes showed good quality attributes including relatively high entrapment efficiency (?50%), association of Tween 40 with vesicles in a constant proportion (?87%), biphasic release profile suitable for inhibiting early bacterial colonization, and long-term stability at 4°C for a 12-month study period. Niosomes significantly enhanced VCM activity against planktonic bacteria of nine staphylococcal strains. Using microtiter plates as abiotic surface, VCM-eluting niosomes proved superior to VCM in inhibiting biofilm formation, eradicating surface-borne biofilms, inhibiting biofilm growth, and interfering with biofilm induction by VCM subminimal inhibitory concentrations. Data suggest dual functionality of cosurfactant VCM-eluting niosomes as passive colonization inhibiting barrier and active antimicrobial-controlled delivery system, two functions recognized in infection control of abiotic surfaces and medical devices.
  • |Anti-Bacterial Agents/*administration & dosage/*pharmacology [MESH]
  • |Biofilms/*drug effects/growth & development [MESH]
  • |Electrochemistry [MESH]
  • |Excipients [MESH]
  • |Liposomes/*chemistry [MESH]
  • |Microbial Sensitivity Tests [MESH]
  • |Particle Size [MESH]
  • |Polysorbates [MESH]
  • |Staphylococcus aureus/*drug effects/growth & development [MESH]


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