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10.2337/dc13-1904 http://scihub22266oqcxt.onion/10.2337/dc13-1904 C4179516!4179516 !24855156     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24855156 &cmd=llinks): Failed to open stream: HTTP request failed! 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Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children |pdf=|usr=}}{{24855156 }} gab.com Text Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children JO: Diabetes Care http://www.kidney.de/pget.php?&tw=1&pmid=24855156 #FOAvip OBJECTIVE: To investigate the impact of new-onset diabetic ketoacidosis (DKA) during childhood on brain morphology and function. RESEARCH DESIGN AND METHODS: Patients aged 6-18 years with and without DKA at diagnosis were studied at four time points: <48 h, 5 days, 28 days, and 6 months postdiagnosis. Patients underwent magnetic resonance imaging (MRI) and spectroscopy with cognitive assessment at each time point. Relationships between clinical characteristics at presentation and MRI and neurologic outcomes were examined using multiple linear regression, repeated-measures, and ANCOVA analyses. RESULTS: Thirty-six DKA and 59 non-DKA patients were recruited between 2004 and 2009. With DKA, cerebral white matter showed the greatest alterations with increased total white matter volume and higher mean diffusivity in the frontal, temporal, and parietal white matter. Total white matter volume decreased over the first 6 months. For gray matter in DKA patients, total volume was lower at baseline and increased over 6 months. Lower levels of N-acetylaspartate were noted at baseline in the frontal gray matter and basal ganglia. Mental state scores were lower at baseline and at 5 days. Of note, although changes in total and regional brain volumes over the first 5 days resolved, they were associated with poorer delayed memory recall and poorer sustained and divided attention at 6 months. Age at time of presentation and pH level were predictors of neuroimaging and functional outcomes. CONCLUSIONS: DKA at type 1 diabetes diagnosis results in morphologic and functional brain changes. These changes are associated with adverse neurocognitive outcomes in the medium term. Twit Text FOAVip Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children ????Diabetes Care http://www.kidney.de/pget.php?&tw=1&pmid=24855156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24855156 #FOAvip English Wikipedia <ref>{{Cite pmid|24855156 }}</ref> Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children #MMPMID24855156 Cameron FJ ; Scratch SE ; Nadebaum C ; Northam EA ; Koves I ; Jennings J ; Finney K ; Neil JJ ; Wellard RM ; Mackay M ; Inder TE Diabetes Care 2014[Jun]; 37 (6 ): 1554-62 PMID24855156 show ga OBJECTIVE: To investigate the impact of new-onset diabetic ketoacidosis (DKA) during childhood on brain morphology and function. RESEARCH DESIGN AND METHODS: Patients aged 6-18 years with and without DKA at diagnosis were studied at four time points: <48 h, 5 days, 28 days, and 6 months postdiagnosis. Patients underwent magnetic resonance imaging (MRI) and spectroscopy with cognitive assessment at each time point. Relationships between clinical characteristics at presentation and MRI and neurologic outcomes were examined using multiple linear regression, repeated-measures, and ANCOVA analyses. RESULTS: Thirty-six DKA and 59 non-DKA patients were recruited between 2004 and 2009. With DKA, cerebral white matter showed the greatest alterations with increased total white matter volume and higher mean diffusivity in the frontal, temporal, and parietal white matter. Total white matter volume decreased over the first 6 months. For gray matter in DKA patients, total volume was lower at baseline and increased over 6 months. Lower levels of N-acetylaspartate were noted at baseline in the frontal gray matter and basal ganglia. Mental state scores were lower at baseline and at 5 days. Of note, although changes in total and regional brain volumes over the first 5 days resolved, they were associated with poorer delayed memory recall and poorer sustained and divided attention at 6 months. Age at time of presentation and pH level were predictors of neuroimaging and functional outcomes. CONCLUSIONS: DKA at type 1 diabetes diagnosis results in morphologic and functional brain changes. These changes are associated with adverse neurocognitive outcomes in the medium term. |Adolescent [MESH] |Aspartic Acid/analogs & derivatives/metabolism [MESH] |Brain/*pathology [MESH] |Child [MESH] |Cognition Disorders/diagnosis/*etiology/metabolism [MESH] |Diabetes Mellitus, Type 1/*diagnosis [MESH] |Diabetic Ketoacidosis/*complications/metabolism [MESH] |Female [MESH] |Humans [MESH] |Linear Models [MESH] |Longitudinal Studies [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Mental Recall/*physiology [MESH]Neurological consequences of diabetic ketoacidosis at initial presenta(epmc).pdf DeepDyve Pubget Overpricing