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10.1128/JVI.01751-14

http://scihub22266oqcxt.onion/10.1128/JVI.01751-14
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C4178734!4178734!25078695
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suck abstract from ncbi


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pmid25078695      J+Virol 2014 ; 88 (20): 12167-72
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  • Human Herpesvirus 8 Viral Interleukin-6 Signaling through gp130 Promotes Virus Replication in Primary Effusion Lymphoma and Endothelial Cells #MMPMID25078695
  • Cousins E; Gao Y; Sandford G; Nicholas J
  • J Virol 2014[Oct]; 88 (20): 12167-72 PMID25078695show ga
  • The contributions of human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) to virus biology remain unclear. Here we examined the role of vIL-6/gp130 signaling in HHV-8 productive replication in primary effusion lymphoma and endothelial cells. Depletion and depletion-complementation experiments revealed that endoplasmic reticulum-localized vIL-6 activity via gp130 and gp130-activated signal transducer and activator of transcription (STAT) signaling, but not extracellular signal-regulated kinase (ERK) activation, was critical for vIL-6 proreplication activity. Our data significantly extend current understanding of vIL-6 function and associated mechanisms in HHV-8 biology.
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