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10.1681/ASN.2013121264

http://scihub22266oqcxt.onion/10.1681/ASN.2013121264
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C4178448!4178448!24812163
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suck abstract from ncbi

pmid24812163      J+Am+Soc+Nephrol 2014 ; 25 (10): 2151-8
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  • Approaches to Uremia #MMPMID24812163
  • Meyer TW; Hostetter TH
  • J Am Soc Nephrol 2014[Oct]; 25 (10): 2151-8 PMID24812163show ga
  • The development of dialysis was a dramatic step forward in medicine, allowing people who would soon have died because of lack of kidney function to remain alive for years. We have since found, however, that the ?artificial kidney? does not live up fully to its name. Dialysis keeps patients alive but not well. Part of the residual illness that dialysis patients experience is caused by retained waste solutes that dialysis does not remove as well as native kidney function does. New means are available to identify these toxic solutes, about which we currently know remarkably little, and knowledge of these solutes would help us to improve therapy. This review summarizes our current knowledge of toxic solutes and highlights methods being explored to identify additional toxic solutes and to enhance the clearance of these solutes to improve patient outcomes.
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