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10.1016/j.bbagrm.2014.04.019 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2014.04.019 C4177978!4177978!24798077     free     free     free       Biochim+Biophys+Acta 2014 ; 1839 (10): 939-50 Nephropedia Template TP {{tp|p=24798077|t=2014. Structure and function of preQ1 riboswitches |pdf=|usr=}}{{24798077}} gab.com Text Structure and function of preQ1 riboswitches JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24798077 #FOAvip PreQ1 riboswitches help regulate the biosynthesis and transport of PreQ1 (7-aminomethyl-7-deazaguanine), a precursor of the hypermodified guanine nucleotide queuosine (Q), in a number of Firmicutes, Proteobacteria, and Fusobacteria. Queuosine is almost universally found at the wobble position of the anticodon in asparaginyl, tyrosyl, histidyl and aspartyl tRNAs, where it contributes to translational fidelity. Two classes of PreQ1 riboswitches have been identified (PreQ1-I and PreQ1-II), and structures of examples from both classes have been determined. Both classes form H-type pseudoknots upon PreQ1 binding, each of which has distinct unusual features and modes of PreQ1 recognition. These features include an unusually long loop 2 in PreQ1-I pseudoknots and an embedded hairpin in loop 3 in PreQ1-II pseudoknots. PreQ1-I riboswitches are also notable for their unusually small aptamer domain, which has been extensively investigated by NMR, X-ray crystallography, FRET, and other biophysical methods. Here we review the discovery, structural biology, ligand specificity, cation interactions, folding, and dynamics, and applications to biotechnology of PreQ1 riboswitches. Twit Text FOAVip Structure and function of preQ1 riboswitches ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24798077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24798077 #FOAvip English Wikipedia <ref>{{Cite pmid|24798077}}</ref> Structure and function of preQ1 riboswitches #MMPMID24798077 Eichhorn CD; Kang M; Feigon J Biochim Biophys Acta 2014[Oct]; 1839 (10): 939-50 PMID24798077show ga PreQ1 riboswitches help regulate the biosynthesis and transport of PreQ1 (7-aminomethyl-7-deazaguanine), a precursor of the hypermodified guanine nucleotide queuosine (Q), in a number of Firmicutes, Proteobacteria, and Fusobacteria. Queuosine is almost universally found at the wobble position of the anticodon in asparaginyl, tyrosyl, histidyl and aspartyl tRNAs, where it contributes to translational fidelity. Two classes of PreQ1 riboswitches have been identified (PreQ1-I and PreQ1-II), and structures of examples from both classes have been determined. Both classes form H-type pseudoknots upon PreQ1 binding, each of which has distinct unusual features and modes of PreQ1 recognition. These features include an unusually long loop 2 in PreQ1-I pseudoknots and an embedded hairpin in loop 3 in PreQ1-II pseudoknots. PreQ1-I riboswitches are also notable for their unusually small aptamer domain, which has been extensively investigated by NMR, X-ray crystallography, FRET, and other biophysical methods. Here we review the discovery, structural biology, ligand specificity, cation interactions, folding, and dynamics, and applications to biotechnology of PreQ1 riboswitches. äStructure and function of preQ1 riboswitches (epmc).pdf DeepDyve Pubget Overpricing