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10.1016/j.yexcr.2014.06.022 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2014.06.022 C4177976!4177976 !25016284     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25016284 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Cell+Res 2014 ; 328 (1 ): 99-117 Nephropedia Template TP {{tp|p=25016284 |t=2014. microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKK?-mTORC1 axis to regulate renal cancer cell invasion |pdf=|usr=}}{{25016284 }} gab.com Text microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKK -mTORC1 axis to regulate renal cancer cell invasion JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25016284 #FOAvip Renal cancer metastasis may result from oncogenic forces that contribute to the primary tumor. We have recently identified microRNA-21 as an oncogenic driver of renal cancer cells. The mechanism by which miR-21 controls renal cancer cell invasion is poorly understood. We show that miR-21 directly downregulates the proapoptotic protein PDCD4 to increase migration and invasion of ACHN and 786-O renal cancer cells as a result of phosphorylation/activation of Akt and IKK?, which activate NF?B-dependent transcription. Constitutively active (CA) Akt or CA IKK? blocks PDCD4-mediated inhibition and restores renal cancer cell migration and invasion. PDCD4 inhibits mTORC1 activity, which was reversed by CA IKK?. Moreover, CA mTORC1 restores cell migration and invasion inhibited by PDCD4 and dominant negative IKK?. Moreover, PDCD4 negatively regulates mTORC2-dependent Akt phosphorylation upstream of this cascade. We show that PDCD4 forms a complex with rictor, an exclusive component of mTORC2, and that this complex formation is reduced in renal cancer cells due to increased miR-21 expression resulting in enhanced phosphorylation of Akt. Thus our results identify a previously unrecognized signaling node where high miR-21 levels reduce rictor-PDCD4 interaction to increase phosphorylation of Akt and contribute to metastatic fitness of renal cancer cells. Twit Text FOAVip microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKK -mTORC1 axis to regulate renal cancer cell invasion ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25016284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25016284 #FOAvip English Wikipedia <ref>{{Cite pmid|25016284 }}</ref> microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKK?-mTORC1 axis to regulate renal cancer cell invasion #MMPMID25016284 Bera A ; Das F ; Ghosh-Choudhury N ; Kasinath BS ; Abboud HE ; Choudhury GG Exp Cell Res 2014[Oct]; 328 (1 ): 99-117 PMID25016284 show ga Renal cancer metastasis may result from oncogenic forces that contribute to the primary tumor. We have recently identified microRNA-21 as an oncogenic driver of renal cancer cells. The mechanism by which miR-21 controls renal cancer cell invasion is poorly understood. We show that miR-21 directly downregulates the proapoptotic protein PDCD4 to increase migration and invasion of ACHN and 786-O renal cancer cells as a result of phosphorylation/activation of Akt and IKK?, which activate NF?B-dependent transcription. Constitutively active (CA) Akt or CA IKK? blocks PDCD4-mediated inhibition and restores renal cancer cell migration and invasion. PDCD4 inhibits mTORC1 activity, which was reversed by CA IKK?. Moreover, CA mTORC1 restores cell migration and invasion inhibited by PDCD4 and dominant negative IKK?. Moreover, PDCD4 negatively regulates mTORC2-dependent Akt phosphorylation upstream of this cascade. We show that PDCD4 forms a complex with rictor, an exclusive component of mTORC2, and that this complex formation is reduced in renal cancer cells due to increased miR-21 expression resulting in enhanced phosphorylation of Akt. Thus our results identify a previously unrecognized signaling node where high miR-21 levels reduce rictor-PDCD4 interaction to increase phosphorylation of Akt and contribute to metastatic fitness of renal cancer cells. |Apoptosis [MESH] |Apoptosis Regulatory Proteins/*metabolism [MESH] |Blotting, Western [MESH] |Carcinoma, Renal Cell/metabolism/*pathology [MESH] |Carrier Proteins/*metabolism [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Humans [MESH] |I-kappa B Kinase/*metabolism [MESH] |Immunoprecipitation [MESH] |Kidney Neoplasms/metabolism/pathology [MESH] |Kidney Tubules/*metabolism [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |MicroRNAs/*genetics [MESH] |Multiprotein Complexes/*metabolism [MESH] |Neoplasm Invasiveness [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |RNA-Binding Proteins/*metabolism [MESH] |Rapamycin-Insensitive Companion of mTOR Protein [MESH]microRNA-21-induced dissociation of PDCD4 from rictor contributes to (epmc).pdf DeepDyve Pubget Overpricing