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10.1016/j.celrep.2014.08.018 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.08.018 C4177277!4177277!25220463     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25220463&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 8 (6): 1659-67 Nephropedia Template TP {{tp|p=25220463|t=2014. The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages |pdf=|usr=}}{{25220463}} gab.com Text The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25220463 #FOAvip Phosphate concentration is tightly regulated at the cellular and organismal levels. The first metazoan phosphate exporter, XPR1, was recently identified, but its in vivo function remains unknown. In a genetic screen, we identified a mutation in a zebrafish ortholog of human XPR1, xpr1b. xpr1b mutants lack microglia, the specialized macrophages that reside in the brain, and also displayed an osteopetrotic phenotype characteristic of defects in osteoclast function. Transgenic expression studies indicated that xpr1b acts autonomously in developing macrophages. xpr1b mutants displayed no gross developmental defects that may arise from phosphate imbalance. We constructed a targeted mutation of xpr1a, a duplicate of xpr1b in the zebrafish genome, to determine if Xpr1a and Xpr1b have redundant functions. Single mutants for xpr1a were viable, and double mutants for xpr1b;xpr1a were similar to xpr1b single mutants. Our genetic analysis reveals a specific role for the phosphate exporter Xpr1 in differentiation of tissue macrophages. Twit Text FOAVip The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25220463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25220463 #FOAvip English Wikipedia <ref>{{Cite pmid|25220463}}</ref> The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages #MMPMID25220463 Meireles AM; Shiau CE; Guenther C; Sidik H; Kingsley DM; Talbot WS Cell Rep 2014[Sep]; 8 (6): 1659-67 PMID25220463show ga Phosphate concentration is tightly regulated at the cellular and organismal levels. The first metazoan phosphate exporter, XPR1, was recently identified, but its in vivo function remains unknown. In a genetic screen, we identified a mutation in a zebrafish ortholog of human XPR1, xpr1b. xpr1b mutants lack microglia, the specialized macrophages that reside in the brain, and also displayed an osteopetrotic phenotype characteristic of defects in osteoclast function. Transgenic expression studies indicated that xpr1b acts autonomously in developing macrophages. xpr1b mutants displayed no gross developmental defects that may arise from phosphate imbalance. We constructed a targeted mutation of xpr1a, a duplicate of xpr1b in the zebrafish genome, to determine if Xpr1a and Xpr1b have redundant functions. Single mutants for xpr1a were viable, and double mutants for xpr1b;xpr1a were similar to xpr1b single mutants. Our genetic analysis reveals a specific role for the phosphate exporter Xpr1 in differentiation of tissue macrophages. äThe phosphate exporter xpr1b is required for differentiation of tissue(epmc).pdf DeepDyve Pubget Overpricing