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10.1002/eji.201444529 http://scihub22266oqcxt.onion/10.1002/eji.201444529 C4177035!4177035!24894919     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2014 ; 44 (9): 2712-20 Nephropedia Template TP {{tp|p=24894919|t=2014. Both retention and recirculation contribute to long-lived regulatory T cell accumulation in the thymus |pdf=|usr=}}{{24894919}} gab.com Text Both retention and recirculation contribute to long-lived regulatory T cell accumulation in the thymus JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24894919 #FOAvip Natural regulatory T cells (Tregs) acquire their lineage-determining transcription factor Foxp3 during development in the thymus and play an important role in maintaining immunologic tolerance. Here we analyzed the composition of the thymic Treg pool using RAG2-GFP/FoxP3-RFP dual reporter mice and found that a population of long-lived GFP? Tregs exists in the thymus. These long-lived Tregs substantially increased with age, to a point where these Tregs represent >90% of the total thymic Treg pool at 6 months of age. In contrast, long-lived conventional T cells remained at ~15% of the total thymic pool at 6 months of age. Consistent with these studies, we noticed that host-derived Tregs represented a large fraction (~10%) of the total thymic Treg pool in bone marrow chimeras, suggesting that long-lived Tregs also reside in the thymus of these mice. The pool of long-lived Tregs in the thymus was sustained by retention of Tregs in the thymus and by recirculation of peripheral Tregs back into the thymus. These long-lived Tregs were functionally similar to wildtype splenic Tregs, and were able to suppress T cell proliferation to an equivalent extent. Together, these data demonstrate that long-lived Tregs accumulate in the thymus by both retention and recirculation. Twit Text FOAVip Both retention and recirculation contribute to long-lived regulatory T cell accumulation in the thymus ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24894919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24894919 #FOAvip English Wikipedia <ref>{{Cite pmid|24894919}}</ref> Both retention and recirculation contribute to long-lived regulatory T cell accumulation in the thymus #MMPMID24894919 Yang E; Zou T; Leichner TM; Zhang SL; Kambayashi T Eur J Immunol 2014[Sep]; 44 (9): 2712-20 PMID24894919show ga Natural regulatory T cells (Tregs) acquire their lineage-determining transcription factor Foxp3 during development in the thymus and play an important role in maintaining immunologic tolerance. Here we analyzed the composition of the thymic Treg pool using RAG2-GFP/FoxP3-RFP dual reporter mice and found that a population of long-lived GFP? Tregs exists in the thymus. These long-lived Tregs substantially increased with age, to a point where these Tregs represent >90% of the total thymic Treg pool at 6 months of age. In contrast, long-lived conventional T cells remained at ~15% of the total thymic pool at 6 months of age. Consistent with these studies, we noticed that host-derived Tregs represented a large fraction (~10%) of the total thymic Treg pool in bone marrow chimeras, suggesting that long-lived Tregs also reside in the thymus of these mice. The pool of long-lived Tregs in the thymus was sustained by retention of Tregs in the thymus and by recirculation of peripheral Tregs back into the thymus. These long-lived Tregs were functionally similar to wildtype splenic Tregs, and were able to suppress T cell proliferation to an equivalent extent. Together, these data demonstrate that long-lived Tregs accumulate in the thymus by both retention and recirculation. äBoth retention and recirculation contribute to long-lived regulatory T(epmc).pdf DeepDyve Pubget Overpricing