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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Healthc+Mater 2014 ; 3 (10): 1597-607 Nephropedia Template TP
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Multifunctional Skin-like Electronics for Quantitative, Clinical Monitoring of Cutaneous Wound Healing #MMPMID24668927
Hattori Y; Falgout L; Lee W; Jung SY; Poon E; Lee JW; Na I; Geisler A; Sadhwani D; Zhang Y; Su Y; Wang X; Liu Z; Xia J; Cheng H; Webb RC; Bonifas AP; Won P; Jeong JW; Jang KI; Song YM; Nardone B; Nodzenski M; Fan JA; Huang Y; West DP; Paller AS; Alam M; Yeo WH; Rogers JA
Adv Healthc Mater 2014[Oct]; 3 (10): 1597-607 PMID24668927show ga
Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here we report a skin-like electronics platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of ?epidermal? electronics system in a realistic, clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.