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2014 ; 3
(10
): 1597-607
Nephropedia Template TP
gab.com Text
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English Wikipedia
Multifunctional skin-like electronics for quantitative, clinical monitoring of
cutaneous wound healing
#MMPMID24668927
Hattori Y
; Falgout L
; Lee W
; Jung SY
; Poon E
; Lee JW
; Na I
; Geisler A
; Sadhwani D
; Zhang Y
; Su Y
; Wang X
; Liu Z
; Xia J
; Cheng H
; Webb RC
; Bonifas AP
; Won P
; Jeong JW
; Jang KI
; Song YM
; Nardone B
; Nodzenski M
; Fan JA
; Huang Y
; West DP
; Paller AS
; Alam M
; Yeo WH
; Rogers JA
Adv Healthc Mater
2014[Oct]; 3
(10
): 1597-607
PMID24668927
show ga
Non-invasive, biomedical devices have the potential to provide important,
quantitative data for the assessment of skin diseases and wound healing.
Traditional methods either rely on qualitative visual and tactile judgments of a
professional and/or data obtained using instrumentation with forms that do not
readily allow intimate integration with sensitive skin near a wound site. Here,
an electronic sensor platform that can softly and reversibly laminate
perilesionally at wounds to provide highly accurate, quantitative data of
relevance to the management of surgical wound healing is reported. Clinical
studies on patients using thermal sensors and actuators in fractal layouts
provide precise time-dependent mapping of temperature and thermal conductivity of
the skin near the wounds. Analytical and simulation results establish the
fundamentals of the sensing modalities, the mechanics of the system, and
strategies for optimized design. The use of this type of "epidermal" electronics
system in a realistic clinical setting with human subjects establishes a set of
practical procedures in disinfection, reuse, and protocols for quantitative
measurement. The results have the potential to address important unmet needs in
chronic wound management.