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10.1074/jbc.M114.562165

http://scihub22266oqcxt.onion/10.1074/jbc.M114.562165
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C4176241!4176241!25100726
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suck abstract from ncbi


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pmid25100726      J+Biol+Chem 2014 ; 289 (38): 26344-56
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  • Casein Kinase 1 ? Phosphorylates the Wnt Regulator Jade-1 and Modulates Its Activity* #MMPMID25100726
  • Borgal L; Rinschen MM; Dafinger C; Hoff S; Reinert MJ; Lamkemeyer T; Lienkamp SS; Benzing T; Schermer B
  • J Biol Chem 2014[Sep]; 289 (38): 26344-56 PMID25100726show ga
  • Background: Jade-1 localizes to the primary cilium and centrosome and inhibits canonical Wnt signaling.Results: Casein kinase 1 ? phosphorylates Jade-1 at a conserved SLS motif.Conclusion: Jade-1 phosphorylation abrogates its ability to inhibit ?-catenin signaling.Significance: These results contribute to understanding ?-catenin regulation, which is central to discovering new therapeutic targets for diseases involving the Wnt signaling pathway.
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