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10.1074/jbc.M114.565945

http://scihub22266oqcxt.onion/10.1074/jbc.M114.565945
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C4176240!4176240!25100728
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suck abstract from ncbi


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pmid25100728      J+Biol+Chem 2014 ; 289 (38): 26302-13
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  • Insulin Receptor Substrate-4 Binds to Slingshot-1 Phosphatase and Promotes Cofilin Dephosphorylation* #MMPMID25100728
  • Homma Y; Kanno Si; Sasaki K; Nishita M; Yasui A; Asano T; Ohashi K; Mizuno K
  • J Biol Chem 2014[Sep]; 289 (38): 26302-13 PMID25100728show ga
  • Background: Slingshot-1 is a cofilin phosphatase that dephosphorylates and activates actin filament-severing activity of cofilin.Results: Insulin receptor substrate-4 (IRS4) binds to and co-localizes with Slingshot-1 and promotes cofilin dephosphorylation.Conclusion: IRS4 promotes local activation of cofilin via binding to Slingshot-1 and activation of phosphatidylinositol 3-kinase.Significance: Our findings indicate a novel function of IRS4 in Slingshot-1 activation and actin dynamics.
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