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10.1074/jbc.M114.573832

http://scihub22266oqcxt.onion/10.1074/jbc.M114.573832
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suck abstract from ncbi


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pmid25092291
      J+Biol+Chem 2014 ; 289 (38 ): 26566-26573
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  • Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through the AWCON neuron #MMPMID25092291
  • Werner KM ; Perez LJ ; Ghosh R ; Semmelhack MF ; Bassler BL
  • J Biol Chem 2014[Sep]; 289 (38 ): 26566-26573 PMID25092291 show ga
  • In a process known as quorum sensing, bacteria use chemicals called autoinducers for cell-cell communication. Population-wide detection of autoinducers enables bacteria to orchestrate collective behaviors. In the animal kingdom detection of chemicals is vital for success in locating food, finding hosts, and avoiding predators. This behavior, termed chemotaxis, is especially well studied in the nematode Caenorhabditis elegans. Here we demonstrate that the Vibrio cholerae autoinducer (S)-3-hydroxytridecan-4-one, termed CAI-1, influences chemotaxis in C. elegans. C. elegans prefers V. cholerae that produces CAI-1 over a V. cholerae mutant defective for CAI-1 production. The position of the CAI-1 ketone moiety is the key feature driving CAI-1-directed nematode behavior. CAI-1 is detected by the C. elegans amphid sensory neuron AWC(ON). Laser ablation of the AWC(ON) cell, but not other amphid sensory neurons, abolished chemoattraction to CAI-1. These analyses define the structural features of a bacterial-produced signal and the nematode chemosensory neuron that permit cross-kingdom interaction.
  • |Animals [MESH]
  • |Caenorhabditis elegans/cytology/*physiology [MESH]
  • |Chemoreceptor Cells/*physiology [MESH]
  • |Chemotaxis [MESH]
  • |Ketones/chemistry/*metabolism [MESH]
  • |Quorum Sensing [MESH]


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