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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biol+Chem
2014 ; 289
(38
): 26566-26573
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Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule
through the AWCON neuron
#MMPMID25092291
Werner KM
; Perez LJ
; Ghosh R
; Semmelhack MF
; Bassler BL
J Biol Chem
2014[Sep]; 289
(38
): 26566-26573
PMID25092291
show ga
In a process known as quorum sensing, bacteria use chemicals called autoinducers
for cell-cell communication. Population-wide detection of autoinducers enables
bacteria to orchestrate collective behaviors. In the animal kingdom detection of
chemicals is vital for success in locating food, finding hosts, and avoiding
predators. This behavior, termed chemotaxis, is especially well studied in the
nematode Caenorhabditis elegans. Here we demonstrate that the Vibrio cholerae
autoinducer (S)-3-hydroxytridecan-4-one, termed CAI-1, influences chemotaxis in
C. elegans. C. elegans prefers V. cholerae that produces CAI-1 over a V. cholerae
mutant defective for CAI-1 production. The position of the CAI-1 ketone moiety is
the key feature driving CAI-1-directed nematode behavior. CAI-1 is detected by
the C. elegans amphid sensory neuron AWC(ON). Laser ablation of the AWC(ON) cell,
but not other amphid sensory neurons, abolished chemoattraction to CAI-1. These
analyses define the structural features of a bacterial-produced signal and the
nematode chemosensory neuron that permit cross-kingdom interaction.