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10.1074/jbc.M114.560961

http://scihub22266oqcxt.onion/10.1074/jbc.M114.560961
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C4176227!4176227!25074923
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suck abstract from ncbi


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pmid25074923      J+Biol+Chem 2014 ; 289 (38): 26357-67
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  • Activation of the Double-stranded RNA-dependent Protein Kinase PKR by Small Ubiquitin-like Modifier (SUMO)* #MMPMID25074923
  • de la Cruz-Herrera CF; Campagna M; García MA; Marcos-Villar L; Lang V; Baz-Martínez M; Gutiérrez S; Vidal A; Rodríguez MS; Esteban M; Rivas C
  • J Biol Chem 2014[Sep]; 289 (38): 26357-67 PMID25074923show ga
  • Background: The double-stranded RNA-dependent protein kinase PKR plays a critical role in the regulation of protein synthesis, apoptosis, cell proliferation, and stress signaling.Results: SUMO covalently modifies PKR and induces its activation.Conclusion: SUMO is a new PKR kinase coactivator.Significance: SUMO may be implicated in the abnormal activation of PKR found in several diseases.
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