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10.1074/jbc.M114.594812

http://scihub22266oqcxt.onion/10.1074/jbc.M114.594812
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C4175349!4175349!25112877
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suck abstract from ncbi


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pmid25112877      J+Biol+Chem 2014 ; 289 (39): 27134-45
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  • p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers* #MMPMID25112877
  • Kong B; Wang Q; Fung E; Xue K; Tsang BK
  • J Biol Chem 2014[Sep]; 289 (39): 27134-45 PMID25112877show ga
  • Background: Mitochondrial dynamics is involved in the regulation of apoptosis.Results: p53 regulates mitochondrial dynamics by interacting with Prohibitin 1 and subsequent releasing Opa1 for Oma1-mediated processing, thereby promoting apoptosis and chemoresponsiveness.Conclusion: CDDP resistance is in part due to dysregulation of p53-induced, Oma1-mediated L-Opa1 processing and mitochondrial fragmentation.Significance: Understanding the regulation of mitochondrial dynamics may offer new strategies for overcoming chemoresistance.
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