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10.1074/jbc.M114.598763 http://scihub22266oqcxt.onion/10.1074/jbc.M114.598763 C4175336!4175336 !25107905     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25107905 &cmd=llinks): Failed to open stream: HTTP request failed! 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I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling |pdf=|usr=}}{{25107905 }} gab.com Text I B kinase (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor B (NF B) signaling JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25107905 #FOAvip Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKK?), the critical activating kinase in canonical (NF?B) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop phosphate in the activated wild type kinase. We show here that K171E IKK? and K171T IKK? represent kinases that are constitutively active even in the absence of activation loop phosphorylation. Predictive modeling and biochemical studies establish why mutations in a positively charged residue in the cationic pocket of an activation loop phosphorylation-dependent kinase result in constitutive activation. Transcription activator-like effector nuclease-based knock-in mutagenesis provides evidence from a B lymphoid context that K171E IKK? contributes to lymphomagenesis. Twit Text FOAVip I B kinase (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor B (NF B) signaling ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25107905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25107905 #FOAvip English Wikipedia <ref>{{Cite pmid|25107905 }}</ref> I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling #MMPMID25107905 Kai X ; Chellappa V ; Donado C ; Reyon D ; Sekigami Y ; Ataca D ; Louissaint A ; Mattoo H ; Joung JK ; Pillai S J Biol Chem 2014[Sep]; 289 (39 ): 26960-26972 PMID25107905 show ga Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKK?), the critical activating kinase in canonical (NF?B) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop phosphate in the activated wild type kinase. We show here that K171E IKK? and K171T IKK? represent kinases that are constitutively active even in the absence of activation loop phosphorylation. Predictive modeling and biochemical studies establish why mutations in a positively charged residue in the cationic pocket of an activation loop phosphorylation-dependent kinase result in constitutive activation. Transcription activator-like effector nuclease-based knock-in mutagenesis provides evidence from a B lymphoid context that K171E IKK? contributes to lymphomagenesis. |*I-kappa B Kinase/immunology/metabolism [MESH] |*Lymphoma/genetics/metabolism [MESH] |*Mutation, Missense [MESH] |*NF-kappa B/genetics/metabolism [MESH] |*Neoplasm Proteins/genetics/metabolism [MESH] |Amino Acid Substitution [MESH] |HeLa Cells [MESH] |Humans [MESH] |Phosphorylation/genetics [MESH]I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activa(epmc).pdf DeepDyve Pubget Overpricing