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10.1074/jbc.M114.567685

http://scihub22266oqcxt.onion/10.1074/jbc.M114.567685
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C4175329!4175329!25107906
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suck abstract from ncbi


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pmid25107906      J+Biol+Chem 2014 ; 289 (39): 26882-94
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  • Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses* #MMPMID25107906
  • Biswas C; Shah N; Muthu M; La P; Fernando AP; Sengupta S; Yang G; Dennery PA
  • J Biol Chem 2014[Sep]; 289 (39): 26882-94 PMID25107906show ga
  • Background: A 28-kDa HO-1 isoform is induced by oxidative stress and cancer and accumulates in the nucleus.Results: Nuclear HO-1 interacts with Nrf2 and alters expression of its target genes.Conclusion: HO-1 modulates Nrf2 function.Significance: Exploiting the synergistic benefits of the HO-1·Nrf2 protein complex is important for developing therapeutic strategies against oxidative stress or cancer.
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