Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.brainres.2014.03.039 http://scihub22266oqcxt.onion/10.1016/j.brainres.2014.03.039 C4174988!4174988!24709120     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Res 2014 ; ä (ä): 3-14 Nephropedia Template TP {{tp|p=24709120|t=2014. RNA-protein interactions in unstable microsatellite diseases |pdf=|usr=}}{{24709120}} gab.com Text RNA-protein interactions in unstable microsatellite diseases JO: Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=24709120 #FOAvip A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves the formation of RNA repeat structures that interact with, and alter the activities of, various factors required for normal RNA processing as well as additional cellular functions. In this review, we explore the deleterious effects of toxic RNA expression and discuss the various model systems currently available for studying RNA gain-of-function in neurologic diseases. Common themes, including bidirectional transcription and repeat-associated non-ATG (RAN) translation, have recently emerged from expansion disease studies. These and other discoveries have highlighted the need for further investigations designed to provide the additional mechanistic insights essential for future therapeutic development. Twit Text FOAVip RNA-protein interactions in unstable microsatellite diseases ????Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=24709120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24709120 #FOAvip English Wikipedia <ref>{{Cite pmid|24709120}}</ref> RNA-protein interactions in unstable microsatellite diseases #MMPMID24709120 Mohan A; Goodwin M; Swanson MS Brain Res 2014[Oct]; ä (ä): 3-14 PMID24709120show ga A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves the formation of RNA repeat structures that interact with, and alter the activities of, various factors required for normal RNA processing as well as additional cellular functions. In this review, we explore the deleterious effects of toxic RNA expression and discuss the various model systems currently available for studying RNA gain-of-function in neurologic diseases. Common themes, including bidirectional transcription and repeat-associated non-ATG (RAN) translation, have recently emerged from expansion disease studies. These and other discoveries have highlighted the need for further investigations designed to provide the additional mechanistic insights essential for future therapeutic development. äRNA-protein interactions in unstable microsatellite diseases (epmc).pdf DeepDyve Pubget Overpricing