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10.1369/0022155414529595

http://scihub22266oqcxt.onion/10.1369/0022155414529595
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C4174625!4174625!24670793
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suck abstract from ncbi


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pmid24670793      J+Histochem+Cytochem 2014 ; 62 (6): 436-49
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  • Marginal Zone Macrophage Receptor MARCO Is Trapped in Conduits Formed by Follicular Dendritic Cells in the Spleen #MMPMID24670793
  • Kellermayer Z; Fisi V; Mihalj M; Berta G; Kóbor J; Balogh P
  • J Histochem Cytochem 2014[Jun]; 62 (6): 436-49 PMID24670793show ga
  • The marginal zone (MZ) region of the spleen plays an important role in leukocyte traffic and the removal of blood-borne pathogens by resident macrophages. Macrophage receptor with a collagenous structure (MARCO), expressed by MZ macrophages, recognizes several microbial ligands and is also involved in the retention of MZ B cells. Here, we report that MARCO is also associated with follicular dendritic cells (FDCs) in the spleen. In its FDC-associated form MARCO is arranged in 0.3?0.5-?m diameter granular-fibrillar structures with an appearance similar to the white pulp conduit system formed by fibroblastic reticular cells (FRCs), but with different compartment preference. The follicular display of MARCO resists irradiation and requires the presence of both MZ macrophages and differentiated FDCs. The follicular delivery of MARCO is independent from the shuffling of marginal zone B cells, and it persists after clodronate liposome-mediated depletion of MZ macrophages. Our findings thus indicate that MARCO is distributed to both MZ and follicles within the spleen into conduit-like structures, where FDC-bound MARCO may mediate communication between the stromal microenvironments of MZ and follicles.
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