Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24670793
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Histochem+Cytochem
2014 ; 62
(6
): 436-449
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Marginal Zone Macrophage Receptor MARCO Is Trapped in Conduits Formed by
Follicular Dendritic Cells in the Spleen
#MMPMID24670793
Kellermayer Z
; Fisi V
; Mihalj M
; Berta G
; Kóbor J
; Balogh P
J Histochem Cytochem
2014[Jun]; 62
(6
): 436-449
PMID24670793
show ga
The marginal zone (MZ) region of the spleen plays an important role in leukocyte
traffic and the removal of blood-borne pathogens by resident macrophages.
Macrophage receptor with a collagenous structure (MARCO), expressed by MZ
macrophages, recognizes several microbial ligands and is also involved in the
retention of MZ B cells. Here, we report that MARCO is also associated with
follicular dendritic cells (FDCs) in the spleen. In its FDC-associated form MARCO
is arranged in 0.3-0.5-?m diameter granular-fibrillar structures with an
appearance similar to the white pulp conduit system formed by fibroblastic
reticular cells (FRCs), but with different compartment preference. The follicular
display of MARCO resists irradiation and requires the presence of both MZ
macrophages and differentiated FDCs. The follicular delivery of MARCO is
independent from the shuffling of marginal zone B cells, and it persists after
clodronate liposome-mediated depletion of MZ macrophages. Our findings thus
indicate that MARCO is distributed to both MZ and follicles within the spleen
into conduit-like structures, where FDC-bound MARCO may mediate communication
between the stromal microenvironments of MZ and follicles.