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10.1037/bne0000012

http://scihub22266oqcxt.onion/10.1037/bne0000012
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C4172664!4172664!25111335
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suck abstract from ncbi


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pmid25111335      Behav+Neurosci 2014 ; 128 (5): 579-87
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  • Extinction and Reinstatement of Phasic Dopamine Signals in the Nucleus Accumbens Core during Pavlovian Conditioning #MMPMID25111335
  • Sunsay C; Rebec GV
  • Behav Neurosci 2014[Oct]; 128 (5): 579-87 PMID25111335show ga
  • The prediction-error model of dopamine (DA) signaling has largely been confirmed with various appetitive Pavlovian conditioning procedures and has been supported in tests of Pavlovian extinction. Studies have repeatedly shown, however, that extinction does not erase the original memory of conditioning as the prediction-error model presumes, putting the model at odds with contemporary views that treat extinction as an episode of learning rather than unlearning of conditioning. Here, we combined fast-scan cyclic voltammetry (FSCV) with appetitive Pavlovian conditioning to assess DA release directly during extinction and reinstatement. DA was monitored in the nucleus accumbens core (NAc), which plays a key role in reward processing. Following at least 4 daily sessions of 16 tone-food pairings, FSCV was performed while rats received additional tone-food pairings followed by tone alone presentations (i.e., extinction). Acquisition memory was reinstated with non-contingent presentations of reward and then tested with cue presentation. Tone-food pairings produced transient (1?3 s) DA release in response to tone. During extinction, the amplitude of the DA response decreased significantly. Following presentation of two non-contingent food pellets, subsequent tone presentation reinstated the DA signal. Our results support the prediction-error model for appetitive Pavlovian extinction but not for reinstatement.
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