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10.1037/bne0000012 http://scihub22266oqcxt.onion/10.1037/bne0000012 C4172664!4172664 !25111335     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25111335 &cmd=llinks): Failed to open stream: HTTP request failed! 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Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning |pdf=|usr=}}{{25111335 }} gab.com Text Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning JO: Behav Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25111335 #FOAvip The prediction-error model of dopamine (DA) signaling has largely been confirmed with various appetitive Pavlovian conditioning procedures and has been supported in tests of Pavlovian extinction. Studies have repeatedly shown, however, that extinction does not erase the original memory of conditioning as the prediction-error model presumes, putting the model at odds with contemporary views that treat extinction as an episode of learning rather than unlearning of conditioning. Here, we combined fast-scan cyclic voltammetry (FSCV) with appetitive Pavlovian conditioning to assess DA release directly during extinction and reinstatement. DA was monitored in the nucleus accumbens core, which plays a key role in reward processing. Following at least 4 daily sessions of 16 tone-food pairings, fast-scan cyclic voltammetry was performed while rats received additional tone-food pairings followed by tone alone presentations (i.e., extinction). Acquisition memory was reinstated with noncontingent presentations of reward and then tested with cue presentation. Tone-food pairings produced transient (1- to 3-s) DA release in response to tone. During extinction, the amplitude of the DA response decreased significantly. Following presentation of 2 noncontingent food pellets, subsequent tone presentation reinstated the DA signal. Our results support the prediction-error model for appetitive Pavlovian extinction but not for reinstatement. Twit Text FOAVip Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning ????Behav Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25111335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25111335 #FOAvip English Wikipedia <ref>{{Cite pmid|25111335 }}</ref> Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning #MMPMID25111335 Sunsay C ; Rebec GV Behav Neurosci 2014[Oct]; 128 (5 ): 579-87 PMID25111335 show ga The prediction-error model of dopamine (DA) signaling has largely been confirmed with various appetitive Pavlovian conditioning procedures and has been supported in tests of Pavlovian extinction. Studies have repeatedly shown, however, that extinction does not erase the original memory of conditioning as the prediction-error model presumes, putting the model at odds with contemporary views that treat extinction as an episode of learning rather than unlearning of conditioning. Here, we combined fast-scan cyclic voltammetry (FSCV) with appetitive Pavlovian conditioning to assess DA release directly during extinction and reinstatement. DA was monitored in the nucleus accumbens core, which plays a key role in reward processing. Following at least 4 daily sessions of 16 tone-food pairings, fast-scan cyclic voltammetry was performed while rats received additional tone-food pairings followed by tone alone presentations (i.e., extinction). Acquisition memory was reinstated with noncontingent presentations of reward and then tested with cue presentation. Tone-food pairings produced transient (1- to 3-s) DA release in response to tone. During extinction, the amplitude of the DA response decreased significantly. Following presentation of 2 noncontingent food pellets, subsequent tone presentation reinstated the DA signal. Our results support the prediction-error model for appetitive Pavlovian extinction but not for reinstatement. |Animals [MESH] |Conditioning, Classical/*physiology [MESH] |Cues [MESH] |Dopamine/*metabolism [MESH] |Extinction, Psychological/*physiology [MESH] |Feeding Behavior/*physiology [MESH] |Male [MESH] |Models, Psychological [MESH] |Nucleus Accumbens/*physiology [MESH] |Rats, Sprague-Dawley [MESH]Extinction and reinstatement of phasic dopamine signals in the nucleus(epmc).pdf DeepDyve Pubget Overpricing