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10.1016/j.bbrc.2014.07.086 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2014.07.086 C4172635!4172635!25078622     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2014 ; 452 (2): 276-86 Nephropedia Template TP {{tp|p=25078622|t=2014. Integrative Genomics of Chronic Obstructive Pulmonary Disease |pdf=|usr=}}{{25078622}} gab.com Text Integrative Genomics of Chronic Obstructive Pulmonary Disease JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=25078622 #FOAvip Chronic obstructive pulmonary disease (COPD) is a complex disease with both environmental and genetic determinants, the most important of which is cigarette smoking. There is marked heterogeneity in the development of COPD among persons with similar cigarette smoking histories, which is likely partially explained by genetic variation. Genomic approaches such as genomewide association studies and gene expression studies have been used to discover genes and molecular pathways involved in COPD pathogenesis; however, these ?first generation? omics studies have limitations. Integrative genomic studies are emerging which can combine genomic datasets to further examine the molecular underpinnings of COPD. Future research in COPD genetics will likely use network-based approaches to integrate multiple genomic data types in order to model the complex molecular interactions involved in COPD pathogenesis. This article reviews the genomic research to date and offers a vision for the future of integrative genomic research in COPD. Twit Text FOAVip Integrative Genomics of Chronic Obstructive Pulmonary Disease ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=25078622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25078622 #FOAvip English Wikipedia <ref>{{Cite pmid|25078622}}</ref> Integrative Genomics of Chronic Obstructive Pulmonary Disease #MMPMID25078622 Hobbs BD; Hersh CP Biochem Biophys Res Commun 2014[Sep]; 452 (2): 276-86 PMID25078622show ga Chronic obstructive pulmonary disease (COPD) is a complex disease with both environmental and genetic determinants, the most important of which is cigarette smoking. There is marked heterogeneity in the development of COPD among persons with similar cigarette smoking histories, which is likely partially explained by genetic variation. Genomic approaches such as genomewide association studies and gene expression studies have been used to discover genes and molecular pathways involved in COPD pathogenesis; however, these ?first generation? omics studies have limitations. Integrative genomic studies are emerging which can combine genomic datasets to further examine the molecular underpinnings of COPD. Future research in COPD genetics will likely use network-based approaches to integrate multiple genomic data types in order to model the complex molecular interactions involved in COPD pathogenesis. This article reviews the genomic research to date and offers a vision for the future of integrative genomic research in COPD. äIntegrative Genomics of Chronic Obstructive Pulmonary Disease (epmc).pdf DeepDyve Pubget Overpricing