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10.1111/imm.12310 http://scihub22266oqcxt.onion/10.1111/imm.12310 C4172145!4172145 !24773389     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24773389 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2014 ; 143 (2 ): 300-9 Nephropedia Template TP {{tp|p=24773389 |t=2014. Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination |pdf=|usr=}}{{24773389 }} gab.com Text Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=24773389 #FOAvip The ectodomain of matrix protein 2 (M2e) of influenza virus is considered a rational target for a universal influenza A vaccine. To better understand M2e immune-mediated protection, Fc receptor common ? chain deficient (FcR?(-/-) ) and wild-type mice were immunized with a tandem repeat of M2e presented on virus-like particles (M2e5x VLP). Levels of M2e-specific antibodies that were induced in FcR?(-/-) mice after immunization with M2e5x VLP were similar to those in wild-type mice. In addition, M2e antibodies induced in FcR?(-/-) mice were found to be equally protective as those induced in wild-type mice. However, M2e5x VLP-immunized FcR?(-/-) mice were not well protected, as shown by severe weight loss, higher lung viral titres and interleukin-6 inflammatory cytokine production upon influenza virus challenge compared with M2e5x VLP-immunized wild-type mice. Importantly, FcR?(-/-) mice that were immunized with inactivated influenza virus induced haemagglutination inhibition activity and were well protected without a significant weight loss. Interestingly, interferon-?-producing CD4 T and CD8 T cells were found to be prevalent in lungs from M2e5x VLP-immunized FcR?(-/-) mice, which appeared to be correlated with a faster recovery after infection. These results indicate that Fc receptors play a primary role in conferring M2e-specific antibody-mediated protection whereas T cells may contribute to the recovery at later stages of infection. Twit Text FOAVip Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=24773389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24773389 #FOAvip English Wikipedia <ref>{{Cite pmid|24773389 }}</ref> Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination #MMPMID24773389 Lee YN ; Lee YT ; Kim MC ; Hwang HS ; Lee JS ; Kim KH ; Kang SM Immunology 2014[Oct]; 143 (2 ): 300-9 PMID24773389 show ga The ectodomain of matrix protein 2 (M2e) of influenza virus is considered a rational target for a universal influenza A vaccine. To better understand M2e immune-mediated protection, Fc receptor common ? chain deficient (FcR?(-/-) ) and wild-type mice were immunized with a tandem repeat of M2e presented on virus-like particles (M2e5x VLP). Levels of M2e-specific antibodies that were induced in FcR?(-/-) mice after immunization with M2e5x VLP were similar to those in wild-type mice. In addition, M2e antibodies induced in FcR?(-/-) mice were found to be equally protective as those induced in wild-type mice. However, M2e5x VLP-immunized FcR?(-/-) mice were not well protected, as shown by severe weight loss, higher lung viral titres and interleukin-6 inflammatory cytokine production upon influenza virus challenge compared with M2e5x VLP-immunized wild-type mice. Importantly, FcR?(-/-) mice that were immunized with inactivated influenza virus induced haemagglutination inhibition activity and were well protected without a significant weight loss. Interestingly, interferon-?-producing CD4 T and CD8 T cells were found to be prevalent in lungs from M2e5x VLP-immunized FcR?(-/-) mice, which appeared to be correlated with a faster recovery after infection. These results indicate that Fc receptors play a primary role in conferring M2e-specific antibody-mediated protection whereas T cells may contribute to the recovery at later stages of infection. |*Vaccination [MESH] |Animals [MESH] |Antibodies, Viral/*blood [MESH] |CD4-Positive T-Lymphocytes/immunology/virology [MESH] |CD8-Positive T-Lymphocytes/immunology/virology [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Hemagglutination [MESH] |Inflammation Mediators/blood [MESH] |Influenza Vaccines/administration & dosage/*immunology [MESH] |Interferon-gamma/metabolism [MESH] |Interleukin-6/blood [MESH] |Lung/*immunology/virology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH] |Orthomyxoviridae Infections/blood/genetics/immunology/*prevention & control/virology [MESH] |Receptors, IgG/deficiency/genetics/*metabolism [MESH] |Remission Induction [MESH] |Time Factors [MESH] |Viral Load [MESH] |Viral Matrix Proteins/administration & dosage/*immunology [MESH]Fc receptor is not required for inducing antibodies but plays a critic(epmc).pdf DeepDyve Pubget Overpricing