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10.1016/j.stem.2014.06.007 http://scihub22266oqcxt.onion/10.1016/j.stem.2014.06.007 C4171737!4171737 !25017721     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25017721 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stem+Cell 2014 ; 15 (3 ): 326-339 Nephropedia Template TP {{tp|p=25017721 |t=2014. Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment |pdf=|usr=}}{{25017721 }} gab.com Text Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25017721 #FOAvip Planarians are flatworms capable of regenerating any missing body region. This capacity is mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells. Although population-based studies have revealed many neoblast characteristics, whether functionally distinct classes exist within this population is unclear. Here, we used high-dimensional single-cell transcriptional profiling from over a thousand individual neoblasts to directly compare gene expression fingerprints during homeostasis and regeneration. We identified two prominent neoblast classes that we named ? (zeta) and ? (sigma). Zeta-neoblasts encompass specified cells that give rise to an abundant postmitotic lineage, including epidermal cells, and are not required for regeneration. By contrast, sigma-neoblasts proliferate in response to injury, possess broad lineage capacity, and can give rise to zeta-neoblasts. These findings indicate that planarian neoblasts comprise two major and functionally distinct cellular compartments. Twit Text FOAVip Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25017721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25017721 #FOAvip English Wikipedia <ref>{{Cite pmid|25017721 }}</ref> Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment #MMPMID25017721 van Wolfswinkel JC ; Wagner DE ; Reddien PW Cell Stem Cell 2014[Sep]; 15 (3 ): 326-339 PMID25017721 show ga Planarians are flatworms capable of regenerating any missing body region. This capacity is mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells. Although population-based studies have revealed many neoblast characteristics, whether functionally distinct classes exist within this population is unclear. Here, we used high-dimensional single-cell transcriptional profiling from over a thousand individual neoblasts to directly compare gene expression fingerprints during homeostasis and regeneration. We identified two prominent neoblast classes that we named ? (zeta) and ? (sigma). Zeta-neoblasts encompass specified cells that give rise to an abundant postmitotic lineage, including epidermal cells, and are not required for regeneration. By contrast, sigma-neoblasts proliferate in response to injury, possess broad lineage capacity, and can give rise to zeta-neoblasts. These findings indicate that planarian neoblasts comprise two major and functionally distinct cellular compartments. |*Cell Compartmentation [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |Cell Cycle [MESH] |Cell Lineage [MESH] |Epidermal Cells [MESH] |Gene Expression Profiling [MESH] |Planarians/*cytology [MESH] |Pluripotent Stem Cells/cytology [MESH] |RNA Interference [MESH] |Regeneration [MESH] |Single-Cell Analysis/*methods [MESH]Single-cell analysis reveals functionally distinct classes within the (epmc).pdf DeepDyve Pubget Overpricing