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10.1016/j.immuni.2014.08.015 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.08.015 C4171711!4171711 !25238096     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25238096 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2014 ; 41 (3 ): 389-401 Nephropedia Template TP {{tp|p=25238096 |t=2014. The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors |pdf=|usr=}}{{25238096 }} gab.com Text The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25238096 #FOAvip Adaptation of malignant cells to the hostile milieu present in tumors is an important determinant of their survival and growth. However, the interaction between tumor-linked stress and antitumor immunity remains poorly characterized. Here, we show the critical role of the cellular stress sensor C/EBP-homologous protein (Chop) in the accumulation and immune inhibitory activity of tumor-infiltrating myeloid-derived suppressor cells (MDSCs). MDSCs lacking Chop had decreased immune-regulatory functions and showed the ability to prime T cell function and induce antitumor responses. Chop expression in MDSCs was induced by tumor-linked reactive oxygen and nitrogen species and regulated by the activating-transcription factor-4. Chop-deficient MDSCs displayed reduced signaling through CCAAT/enhancer-binding protein-?, leading to a decreased production of interleukin-6 (IL-6) and low expression of phospho-STAT3. IL-6 overexpression restored immune-suppressive activity of Chop-deficient MDSCs. These findings suggest the role of Chop in tumor-induced tolerance and the therapeutic potential of targeting Chop in MDSCs for cancer immunotherapy. Twit Text FOAVip The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25238096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25238096 #FOAvip English Wikipedia <ref>{{Cite pmid|25238096 }}</ref> The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors #MMPMID25238096 Thevenot PT ; Sierra RA ; Raber PL ; Al-Khami AA ; Trillo-Tinoco J ; Zarreii P ; Ochoa AC ; Cui Y ; Del Valle L ; Rodriguez PC Immunity 2014[Sep]; 41 (3 ): 389-401 PMID25238096 show ga Adaptation of malignant cells to the hostile milieu present in tumors is an important determinant of their survival and growth. However, the interaction between tumor-linked stress and antitumor immunity remains poorly characterized. Here, we show the critical role of the cellular stress sensor C/EBP-homologous protein (Chop) in the accumulation and immune inhibitory activity of tumor-infiltrating myeloid-derived suppressor cells (MDSCs). MDSCs lacking Chop had decreased immune-regulatory functions and showed the ability to prime T cell function and induce antitumor responses. Chop expression in MDSCs was induced by tumor-linked reactive oxygen and nitrogen species and regulated by the activating-transcription factor-4. Chop-deficient MDSCs displayed reduced signaling through CCAAT/enhancer-binding protein-?, leading to a decreased production of interleukin-6 (IL-6) and low expression of phospho-STAT3. IL-6 overexpression restored immune-suppressive activity of Chop-deficient MDSCs. These findings suggest the role of Chop in tumor-induced tolerance and the therapeutic potential of targeting Chop in MDSCs for cancer immunotherapy. |Activating Transcription Factor 4/genetics/metabolism [MESH] |Animals [MESH] |Bone Marrow Cells/immunology [MESH] |Bone Marrow Transplantation [MESH] |CCAAT-Enhancer-Binding Protein-beta/*immunology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Endothelial Cells/metabolism [MESH] |Female [MESH] |Interleukin-6/biosynthesis [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Myeloid Cells/immunology [MESH] |Neoplasms [MESH] |Neovascularization, Pathologic/genetics/immunology [MESH] |Reactive Nitrogen Species/immunology [MESH] |Reactive Oxygen Species/immunology [MESH] |STAT3 Transcription Factor/biosynthesis [MESH] |T-Lymphocytes/*immunology [MESH] |Transcription Factor CHOP/biosynthesis/*genetics [MESH]The stress-response sensor chop regulates the function and accumulatio(epmc).pdf DeepDyve Pubget Overpricing