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10.1002/ar.23000

http://scihub22266oqcxt.onion/10.1002/ar.23000
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C4170232!4170232!25132345
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suck abstract from ncbi


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pmid25132345      Anat+Rec+(Hoboken) 2014 ; 297 (10): 1865-84
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  • Laminar and neurochemical organization of the dorsal cochlear nucleus of the human, monkey, cat, and rodents #MMPMID25132345
  • Baizer JS; Wong KM; Paolone NA; Weinstock N; Salvi RJ; Manohar S; Witelson SF; Baker JF; Sherwood CC; Hof PR
  • Anat Rec (Hoboken) 2014[Oct]; 297 (10): 1865-84 PMID25132345show ga
  • The dorsal cochlear nucleus (DCN) is a brainstem structure that receives input from the auditory nerve. Many studies in a diversity of species have shown that the DCN has a laminar organization and identifiable neuron types with predictable synaptic relations to each other. In contrast, studies on the human DCN have found a less distinct laminar organization and fewer cell types, although there has been disagreement among studies in how to characterize laminar organization and which of the cell types identified in other animals are also present in humans. We have reexamined DCN organization in the human using immunohistochemistry to analyze the expression of several proteins that have been useful in delineating the neurochemical organization of other brainstem structures in humans: nonphosphorylated neurofilament protein (NPNFP), nitric oxide synthase (nNOS), and three calcium-binding proteins. The results for humans suggest a laminar organization with only two layers, and the presence of large projection neurons that are enriched in NPNFP. We did not observe evidence in humans of the inhibitory interneurons that have been described in the cat and rodent DCN. To compare humans and other animals directly we used immunohistochemistry to examine the DCN in the macaque monkey, the cat, and three rodents. We found similarities between macaque monkey and human in the expression of NPNFP and nNOS, and unexpected differences among species in the patterns of expression of the calcium-binding proteins.
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