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10.1016/j.molcel.2014.07.019 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.07.019 C4169768!4169768 !25175026     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25175026 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2014 ; 55 (6 ): 916-930 Nephropedia Template TP {{tp|p=25175026 |t=2014. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity |pdf=|usr=}}{{25175026 }} gab.com Text Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25175026 #FOAvip Ras-driven cancer cells upregulate basal autophagy that degrades and recycles intracellular proteins and organelles. Autophagy-mediated proteome degradation provides free amino acids to support metabolism and macromolecular synthesis, which confers a survival advantage in starvation and promotes tumorigenesis. While the degradation of isolated protein substrates by autophagy has been implicated in controlling cellular function, the extent and specificity by which autophagy remodels the cellular proteome and the underlying functional consequences were unknown. Here we compared the global proteome of autophagy-functional and -deficient Ras-driven cancer cells, finding that autophagy affects the majority of the proteome yet is highly selective. While levels of vesicle trafficking proteins important for autophagy are preserved during starvation-induced autophagy, deleterious inflammatory response pathway components are eliminated even under basal conditions, preventing cytokine-induced paracrine cell death. This reveals the global, functional impact of autophagy-mediated proteome remodeling on cell survival and identifies critical autophagy substrates that mediate this process. Twit Text FOAVip Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25175026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25175026 #FOAvip English Wikipedia <ref>{{Cite pmid|25175026 }}</ref> Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity #MMPMID25175026 Mathew R ; Khor S ; Hackett SR ; Rabinowitz JD ; Perlman DH ; White E Mol Cell 2014[Sep]; 55 (6 ): 916-930 PMID25175026 show ga Ras-driven cancer cells upregulate basal autophagy that degrades and recycles intracellular proteins and organelles. Autophagy-mediated proteome degradation provides free amino acids to support metabolism and macromolecular synthesis, which confers a survival advantage in starvation and promotes tumorigenesis. While the degradation of isolated protein substrates by autophagy has been implicated in controlling cellular function, the extent and specificity by which autophagy remodels the cellular proteome and the underlying functional consequences were unknown. Here we compared the global proteome of autophagy-functional and -deficient Ras-driven cancer cells, finding that autophagy affects the majority of the proteome yet is highly selective. While levels of vesicle trafficking proteins important for autophagy are preserved during starvation-induced autophagy, deleterious inflammatory response pathway components are eliminated even under basal conditions, preventing cytokine-induced paracrine cell death. This reveals the global, functional impact of autophagy-mediated proteome remodeling on cell survival and identifies critical autophagy substrates that mediate this process. |*Autophagy [MESH] |*Immunity, Innate [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Survival [MESH] |Humans [MESH] |Mice [MESH] |Protein Transport [MESH] |Proteome/*physiology [MESH] |Transport Vesicles [MESH]Functional role of autophagy-mediated proteome remodeling in cell surv(epmc).pdf DeepDyve Pubget Overpricing