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10.1038/ni.2986 http://scihub22266oqcxt.onion/10.1038/ni.2986 C4169336!4169336!25194421     free     free     free       Nat+Immunol 2014 ; 15 (10): 920-8 Nephropedia Template TP {{tp|p=25194421|t=2014. Diversification of TAM receptor function |pdf=|usr=}}{{25194421}} gab.com Text Diversification of TAM receptor function JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25194421 #FOAvip Apoptotic cell clearance is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer played distinct roles as phagocytic receptors in these two settings, where they exhibited divergent expression, regulation, and activity. Mer acted as a tolerogenic receptor in resting macrophages and in settings of immune suppression. Conversely, Axl was an inflammatory response receptor whose expression was induced by pro-inflammatory stimuli. Axl and Mer displayed distinct ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation that was triggered by bridging TAM receptor?ligand complexes to the ?eat-me? signal phosphatidylserine on apoptotic cell surfaces. Twit Text FOAVip Diversification of TAM receptor function ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25194421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25194421 #FOAvip English Wikipedia <ref>{{Cite pmid|25194421}}</ref> Diversification of TAM receptor function #MMPMID25194421 Zagórska A; Través PG; Lew ED; Dransfield I; Lemke G Nat Immunol 2014[Oct]; 15 (10): 920-8 PMID25194421show ga Apoptotic cell clearance is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer played distinct roles as phagocytic receptors in these two settings, where they exhibited divergent expression, regulation, and activity. Mer acted as a tolerogenic receptor in resting macrophages and in settings of immune suppression. Conversely, Axl was an inflammatory response receptor whose expression was induced by pro-inflammatory stimuli. Axl and Mer displayed distinct ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation that was triggered by bridging TAM receptor?ligand complexes to the ?eat-me? signal phosphatidylserine on apoptotic cell surfaces. äDiversification of TAM receptor function (epmc).pdf DeepDyve Pubget Overpricing