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10.1161/ATVBAHA.114.303425 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.114.303425 C4169332!4169332!25012134     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2014 ; 34 (10): 2206-16 Nephropedia Template TP {{tp|p=25012134|t=2014. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis ? ?Mechanosensitive Athero-miRs? |pdf=|usr=}}{{25012134}} gab.com Text Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis Mechanosensitive Athero-miRs JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=25012134 #FOAvip Atherosclerosis preferentially occurs in arterial regions exposed to disturbed flow, in part, due to alterations in gene expression. MicroRNAs (miRNAs) are small, noncoding genes that post-transcriptionally regulate gene expression by targeting messenger RNA transcripts. Emerging evidence indicates that alteration of flow conditions regulate expression of miRNAs in endothelial cells both in vitro and in vivo. These flow-sensitive microRNAs, known as ?mechano-miRs?, regulate endothelial gene expression, and can regulate endothelial dysfunction and atherosclerosis. MiRNAs such as, miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, 205, and -155, have been identified as mechano-miRs. Many of these miRNAs were initially identified as flow-sensitive in vitro and were later found to play a critical role in endothelial function and/or atherosclerosis in vivo through either gain-of-function or loss-of-function approaches. The key signaling pathways that are targeted by these mechano-miRs include the endothelial cell cycle, inflammation, apoptosis, and nitric oxide signaling. Furthermore, we have recently shown that the miR-712/205 family, which is upregulated by disturbed flow, contributes to endothelial inflammation and vascular hyper-permeability by targeting tissue inhibitor of metalloproteinase-3 (TIMP3), which regulates metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs). The mechano-miRs that are implicated in atherosclerosis are termed as ?mechanosensitive athero-miRs? and are potential therapeutic targets to prevent or treat atherosclerosis. This review summarizes the current knowledge of mechanosensitive athero-miRs and their role in vascular biology and atherosclerosis. Twit Text FOAVip Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis Mechanosensitive Athero-miRs ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=25012134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25012134 #FOAvip English Wikipedia <ref>{{Cite pmid|25012134}}</ref> Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis ? ?Mechanosensitive Athero-miRs? #MMPMID25012134 Kumar S; Kim CW; Simmons RD; Jo H Arterioscler Thromb Vasc Biol 2014[Oct]; 34 (10): 2206-16 PMID25012134show ga Atherosclerosis preferentially occurs in arterial regions exposed to disturbed flow, in part, due to alterations in gene expression. MicroRNAs (miRNAs) are small, noncoding genes that post-transcriptionally regulate gene expression by targeting messenger RNA transcripts. Emerging evidence indicates that alteration of flow conditions regulate expression of miRNAs in endothelial cells both in vitro and in vivo. These flow-sensitive microRNAs, known as ?mechano-miRs?, regulate endothelial gene expression, and can regulate endothelial dysfunction and atherosclerosis. MiRNAs such as, miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, 205, and -155, have been identified as mechano-miRs. Many of these miRNAs were initially identified as flow-sensitive in vitro and were later found to play a critical role in endothelial function and/or atherosclerosis in vivo through either gain-of-function or loss-of-function approaches. The key signaling pathways that are targeted by these mechano-miRs include the endothelial cell cycle, inflammation, apoptosis, and nitric oxide signaling. Furthermore, we have recently shown that the miR-712/205 family, which is upregulated by disturbed flow, contributes to endothelial inflammation and vascular hyper-permeability by targeting tissue inhibitor of metalloproteinase-3 (TIMP3), which regulates metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs). The mechano-miRs that are implicated in atherosclerosis are termed as ?mechanosensitive athero-miRs? and are potential therapeutic targets to prevent or treat atherosclerosis. This review summarizes the current knowledge of mechanosensitive athero-miRs and their role in vascular biology and atherosclerosis. äRole of flow-sensitive microRNAs in endothelial dysfunction and athero(epmc).pdf DeepDyve Pubget Overpricing