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10.1161/ATVBAHA.114.303422 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.114.303422 C4169328!4169328!24876354     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2014 ; 34 (10): 2191-8 Nephropedia Template TP {{tp|p=24876354|t=2014. Shear stress-initiated signaling and its regulation of endothelial function |pdf=|usr=}}{{24876354}} gab.com Text Shear stress-initiated signaling and its regulation of endothelial function JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24876354 #FOAvip Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of pro-proliferative and pro-inflammatory gene expressions, reduced production of nitric oxide (NO), increased leukocyte adhesion and permeability, as well as other atheroprone phenotypes. Differences in gene expressions and cell phenotypes have been detected in endothelia residing in native atherosusceptible and atheroresistant regions of the arteries, or in arteries from animal models with artificial creation of disturbed flow. Similar results have also been shown in in vitro systems that apply controlled shear stresses with or without clear directions to cultured endothelial cells (ECs) in fluid-dynamically designed flow-loading devices. The available evidence indicates that the coordination of multiple signaling networks, rather than individual separate pathways, link the mechanical signals to specific genetic circuitries in orchestrating the mechanoresponsive networks to evoke comprehensive genetic and functional responses. Twit Text FOAVip Shear stress-initiated signaling and its regulation of endothelial function ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24876354 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24876354 #FOAvip English Wikipedia <ref>{{Cite pmid|24876354}}</ref> Shear stress-initiated signaling and its regulation of endothelial function #MMPMID24876354 Zhou J; Li YS; Chien S Arterioscler Thromb Vasc Biol 2014[Oct]; 34 (10): 2191-8 PMID24876354show ga Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of pro-proliferative and pro-inflammatory gene expressions, reduced production of nitric oxide (NO), increased leukocyte adhesion and permeability, as well as other atheroprone phenotypes. Differences in gene expressions and cell phenotypes have been detected in endothelia residing in native atherosusceptible and atheroresistant regions of the arteries, or in arteries from animal models with artificial creation of disturbed flow. Similar results have also been shown in in vitro systems that apply controlled shear stresses with or without clear directions to cultured endothelial cells (ECs) in fluid-dynamically designed flow-loading devices. The available evidence indicates that the coordination of multiple signaling networks, rather than individual separate pathways, link the mechanical signals to specific genetic circuitries in orchestrating the mechanoresponsive networks to evoke comprehensive genetic and functional responses. äShear stress-initiated signaling and its regulation of endothelial fun(epmc).pdf DeepDyve Pubget Overpricing