Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/ajt.12868 http://scihub22266oqcxt.onion/10.1111/ajt.12868 C4169326!4169326!25220221     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2014 ; 14 (10): 2275-87 Nephropedia Template TP {{tp|p=25220221|t=2014. PIG-TO-MONKEY ISLET XENOTRANSPLANTATION USING MULTI-TRANSGENIC PIGS |pdf=|usr=}}{{25220221}} gab.com Text PIG-TO-MONKEY ISLET XENOTRANSPLANTATION USING MULTI-TRANSGENIC PIGS JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25220221 #FOAvip The generation of pigs with genetic modifications has significantly advanced the field of xenotransplantation. New genetically-engineered pigs were produced on an ?1,3-galactosyltransferase gene-knockout background with ubiquitous expression of human CD46 (GTKO/CD46 pigs), with islet beta cell-specific expression of human tissue factor pathway inhibitor (hTFPI) and/or human CD39 and/or porcine CTLA4-lg. Isolated islets from pigs with 3, 4, or 5 genetic modifications were transplanted intraportally into streptozotocin-diabetic, immunosuppressed cynomolgus monkeys (n=5). Immunosuppression was based on anti-CD154mAb costimulation blockade. Monitoring included features of early islet destruction, glycemia, exogenous insulin requirement, and histopathology of the islets at necropsy. Using these modified pig islets, there was evidence of reduced islet destruction in the first hours after transplantation, compared with two series of historical controls that received identical therapy but were transplanted with islets from pigs with either no or only one genetic modification. Despite encouraging effects on early islet loss, these multi-transgenic islet grafts did not demonstrate consistency in regard to long-term success, with only 2 of 5 demonstrating function beyond 5 months. Twit Text FOAVip PIG-TO-MONKEY ISLET XENOTRANSPLANTATION USING MULTI-TRANSGENIC PIGS ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25220221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25220221 #FOAvip English Wikipedia <ref>{{Cite pmid|25220221}}</ref> PIG-TO-MONKEY ISLET XENOTRANSPLANTATION USING MULTI-TRANSGENIC PIGS #MMPMID25220221 Bottino R; Wijkstrom M; van der Windt D; Hara H; Ezzelarab M; Murase N; Bertera S; He J; Phelps C; Ayares D; Cooper D; Trucco M Am J Transplant 2014[Oct]; 14 (10): 2275-87 PMID25220221show ga The generation of pigs with genetic modifications has significantly advanced the field of xenotransplantation. New genetically-engineered pigs were produced on an ?1,3-galactosyltransferase gene-knockout background with ubiquitous expression of human CD46 (GTKO/CD46 pigs), with islet beta cell-specific expression of human tissue factor pathway inhibitor (hTFPI) and/or human CD39 and/or porcine CTLA4-lg. Isolated islets from pigs with 3, 4, or 5 genetic modifications were transplanted intraportally into streptozotocin-diabetic, immunosuppressed cynomolgus monkeys (n=5). Immunosuppression was based on anti-CD154mAb costimulation blockade. Monitoring included features of early islet destruction, glycemia, exogenous insulin requirement, and histopathology of the islets at necropsy. Using these modified pig islets, there was evidence of reduced islet destruction in the first hours after transplantation, compared with two series of historical controls that received identical therapy but were transplanted with islets from pigs with either no or only one genetic modification. Despite encouraging effects on early islet loss, these multi-transgenic islet grafts did not demonstrate consistency in regard to long-term success, with only 2 of 5 demonstrating function beyond 5 months. äPIG-TO-MONKEY ISLET XENOTRANSPLANTATION USING MULTI-TRANSGENIC PIGS (epmc).pdf DeepDyve Pubget Overpricing