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10.1161/CIRCRESAHA.114.302362 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.114.302362 C4169264!4169264!24763469     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Circ+Res 2014 ; 114 (9): 1532-46 Nephropedia Template TP {{tp|p=24763469|t=2014. AF Therapy Now and in the Future: Drugs, Biologicals, and Ablation |pdf=|usr=}}{{24763469}} gab.com Text AF Therapy Now and in the Future: Drugs, Biologicals, and Ablation JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=24763469 #FOAvip Rationale: Atrial fibrillation (AF) is a complex disease with multiple interrelating causes culminating in rapid, seemingly disorganized atrial activation. Therapy targeting AF is rapidly changing and improving. Objective: The purpose of this review is to summarize current state-of-the-art diagnostic and therapeutic modalities for treatment of atrial fibrillation. The review focuses on reviewing treatment as it relates to the pathophysiological basis of disease and reviews pre-clinical and clinical evidence for potential new diagnostic and therapeutic modalities, including imaging, biomarkers, pharmacologic therapy as well as ablative strategies for AF. Conclusions: Current ablation and drug therapy approaches to treating AF are largely based on treating the arrhythmia once the substrate occurs and is more effective in paroxysmal AF rather than persistent or permanent AF. However, there is much research aimed at prevention strategies, targeting AF substrate?so called upstream therapy. Improved diagnostics, using imaging, genetics and biomarkers are needed to better identify sub-types of AF based on underlying substrate/mechanism to allow more directed therapeutic approaches. In addition, novel anti-arrhythmics with more atrial specific effects may reduce limiting pro-arrhythmic side-effects. Advances in ablation therapy are aimed at improving technology to reduce procedure time and in mechanism targeted approaches. Twit Text FOAVip AF Therapy Now and in the Future: Drugs, Biologicals, and Ablation ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=24763469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24763469 #FOAvip English Wikipedia <ref>{{Cite pmid|24763469}}</ref> AF Therapy Now and in the Future: Drugs, Biologicals, and Ablation #MMPMID24763469 Woods CE; Olgin J Circ Res 2014[Apr]; 114 (9): 1532-46 PMID24763469show ga Rationale: Atrial fibrillation (AF) is a complex disease with multiple interrelating causes culminating in rapid, seemingly disorganized atrial activation. Therapy targeting AF is rapidly changing and improving. Objective: The purpose of this review is to summarize current state-of-the-art diagnostic and therapeutic modalities for treatment of atrial fibrillation. The review focuses on reviewing treatment as it relates to the pathophysiological basis of disease and reviews pre-clinical and clinical evidence for potential new diagnostic and therapeutic modalities, including imaging, biomarkers, pharmacologic therapy as well as ablative strategies for AF. Conclusions: Current ablation and drug therapy approaches to treating AF are largely based on treating the arrhythmia once the substrate occurs and is more effective in paroxysmal AF rather than persistent or permanent AF. However, there is much research aimed at prevention strategies, targeting AF substrate?so called upstream therapy. Improved diagnostics, using imaging, genetics and biomarkers are needed to better identify sub-types of AF based on underlying substrate/mechanism to allow more directed therapeutic approaches. In addition, novel anti-arrhythmics with more atrial specific effects may reduce limiting pro-arrhythmic side-effects. Advances in ablation therapy are aimed at improving technology to reduce procedure time and in mechanism targeted approaches. äAF Therapy Now and in the Future: Drugs, Biologicals, and Ablation (epmc).pdf DeepDyve Pubget Overpricing