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10.1016/j.cub.2014.04.048 http://scihub22266oqcxt.onion/10.1016/j.cub.2014.04.048 C4169046!4169046!24881874     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Biol 2014 ; 24 (12): 1314-22 Nephropedia Template TP {{tp|p=24881874|t=2014. Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation |pdf=|usr=}}{{24881874}} gab.com Text Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=24881874 #FOAvip Background: Autophagy as a conserved lysosomal/vacuolar degradation and recycling pathway is important in normal development and physiology, and defects in this process are linked to many kinds of disease. Because too much or too little autophagy can be detrimental, the process must be tightly regulated both temporally and in magnitude. Two parameters that affect this regulation are the size and the number of autophagosomes; however, although we know that the amount of Atg8 affects the size of autophagosomes, the mechanism for regulating their number has not been elucidated. The transcriptional induction and repression of the autophagy-related (ATG) genes is one crucial aspect of autophagy regulation, but the transcriptional regulators that modulate autophagy are not well characterized. Results: We detected increased expression levels of ATG genes, and elevated autophagy activity, in cells lacking the transcriptional regulator Pho23. Using transmission electron microscopy, we found that PHO23 null mutant cells contain significantly more autophagosomes than the wild-type. By RNA sequencing transcriptome profiling, we identified ATG9 as one of the key targets of Pho23, and our studies with strains expressing modulated levels of Atg9 show that the amount of this protein directly correlates with the frequency of autophagosome formation and the level of autophagy activity. Conclusions: Our results identified Pho23 as a master transcriptional repressor for autophagy that regulates the frequency of autophagosome formation through its negative regulation of ATG9. Twit Text FOAVip Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=24881874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24881874 #FOAvip English Wikipedia <ref>{{Cite pmid|24881874}}</ref> Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation #MMPMID24881874 Jin M; He D; Backues SK; Freeberg MA; Liu X; Kim JK; Klionsky DJ Curr Biol 2014[Jun]; 24 (12): 1314-22 PMID24881874show ga Background: Autophagy as a conserved lysosomal/vacuolar degradation and recycling pathway is important in normal development and physiology, and defects in this process are linked to many kinds of disease. Because too much or too little autophagy can be detrimental, the process must be tightly regulated both temporally and in magnitude. Two parameters that affect this regulation are the size and the number of autophagosomes; however, although we know that the amount of Atg8 affects the size of autophagosomes, the mechanism for regulating their number has not been elucidated. The transcriptional induction and repression of the autophagy-related (ATG) genes is one crucial aspect of autophagy regulation, but the transcriptional regulators that modulate autophagy are not well characterized. Results: We detected increased expression levels of ATG genes, and elevated autophagy activity, in cells lacking the transcriptional regulator Pho23. Using transmission electron microscopy, we found that PHO23 null mutant cells contain significantly more autophagosomes than the wild-type. By RNA sequencing transcriptome profiling, we identified ATG9 as one of the key targets of Pho23, and our studies with strains expressing modulated levels of Atg9 show that the amount of this protein directly correlates with the frequency of autophagosome formation and the level of autophagy activity. Conclusions: Our results identified Pho23 as a master transcriptional repressor for autophagy that regulates the frequency of autophagosome formation through its negative regulation of ATG9. äTranscriptional Regulation by Pho23 Modulates the Frequency of Autopha(epmc).pdf DeepDyve Pubget Overpricing