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10.4161/epi.29856 http://scihub22266oqcxt.onion/10.4161/epi.29856 C4169011!4169011 !25093444     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25093444 &cmd=llinks): Failed to open stream: HTTP request failed! 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Methylome, transcriptome, and PPAR(?) cistrome analyses reveal two epigenetic transitions in fat cells |pdf=|usr=}}{{25093444 }} gab.com Text Methylome, transcriptome, and PPAR( ) cistrome analyses reveal two epigenetic transitions in fat cells JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=25093444 #FOAvip Although DNA modification is adaptive to extrinsic demands, little is known about epigenetic alterations associated with adipose differentiation and reprogramming. We systematically characterized the global trends of our methylome and transcriptome data with reported PPAR(?) cistrome data. Our analysis revealed that DNA methylation was altered between induced pluripotent stem cells (iPSCs) and adipose derived stem cells (ADSCs). Surprisingly, DNA methylation was not obviously changed in differentiation from ADSCs to mature fat cells (FatCs). This indicates that epigenetic predetermination of the adipogenic fate is almost established prior to substantial expression of the lineage. Furthermore, the majority of the PPAR(?) cistrome corresponded to the pre-set methylation profile between ADSCs and FatCs. In contrast to the pre-set model, we found that a subset of PPAR(?)-binding sites for late-expressing genes such as Adiponectin and Adiponectin receptor2 were differentially methylated independently of the early program. Thus, these analyses identify two types of epigenetic mechanisms that distinguish the pre-set cell fate and later stages of adipose differentiation. Twit Text FOAVip Methylome, transcriptome, and PPAR( ) cistrome analyses reveal two epigenetic transitions in fat cells ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=25093444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25093444 #FOAvip English Wikipedia <ref>{{Cite pmid|25093444 }}</ref> Methylome, transcriptome, and PPAR(?) cistrome analyses reveal two epigenetic transitions in fat cells #MMPMID25093444 Takada H ; Saito Y ; Mituyama T ; Wei Z ; Yoshihara E ; Jacinto S ; Downes M ; Evans RM ; Kida YS Epigenetics 2014[Sep]; 9 (9 ): 1195-206 PMID25093444 show ga Although DNA modification is adaptive to extrinsic demands, little is known about epigenetic alterations associated with adipose differentiation and reprogramming. We systematically characterized the global trends of our methylome and transcriptome data with reported PPAR(?) cistrome data. Our analysis revealed that DNA methylation was altered between induced pluripotent stem cells (iPSCs) and adipose derived stem cells (ADSCs). Surprisingly, DNA methylation was not obviously changed in differentiation from ADSCs to mature fat cells (FatCs). This indicates that epigenetic predetermination of the adipogenic fate is almost established prior to substantial expression of the lineage. Furthermore, the majority of the PPAR(?) cistrome corresponded to the pre-set methylation profile between ADSCs and FatCs. In contrast to the pre-set model, we found that a subset of PPAR(?)-binding sites for late-expressing genes such as Adiponectin and Adiponectin receptor2 were differentially methylated independently of the early program. Thus, these analyses identify two types of epigenetic mechanisms that distinguish the pre-set cell fate and later stages of adipose differentiation. |*Cell Differentiation [MESH] |*DNA Methylation [MESH] |*Epigenesis, Genetic [MESH] |*Transcriptome [MESH] |Adipocytes/cytology/*metabolism [MESH] |Adiponectin/metabolism [MESH] |Cell Line [MESH] |Cellular Reprogramming [MESH] |Humans [MESH] |Induced Pluripotent Stem Cells/cytology/metabolism [MESH] |PPAR gamma/genetics/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Receptors, Adiponectin/genetics/metabolism [MESH]Methylome, transcriptome, and PPAR(?) cistrome analyses reveal two epi(epmc).pdf DeepDyve Pubget Overpricing