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10.1111/apt.12921 http://scihub22266oqcxt.onion/10.1111/apt.12921 C4167918!4167918!25164152     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aliment+Pharmacol+Ther 2014 ; 40 (8): 863-79 Nephropedia Template TP {{tp|p=25164152|t=2014. Systematic review: Identifying patients with chronic hepatitis C in need of early treatment and intensive monitoring predictors and predictive models of disease progression |pdf=|usr=}}{{25164152}} gab.com Text Systematic review: Identifying patients with chronic hepatitis C in need of early treatment and intensive monitoring predictors and predictive models of disease progression JO: Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25164152 #FOAvip Background: Advances in hepatitis C therapies have led to increasing numbers of patients seeking treatment. As a result, logistical and financial concerns regarding how treatment can be provided to all patients with chronic hepatitis C (CHC) have emerged. Aim: The aim of this review was to evaluate predictors and predictive models of histologic progression and clinical outcomes for patients with CHC. Methods: MEDLINE via PubMed, EMBASE, Web of Science and Scopus were searched for studies published between January 2003 and June 2014.Two authors independently reviewed articles to select eligible studies and performed data abstraction. Results: Twenty-nine studies representing 5817 patients from 20 unique cohorts were included. The outcome incidence rates were widely variable: 16-61% during median follow-up of 2.5-10 years for fibrosis progression; 13-40% over 2.3-14.4 years for hepatic decompensation; and 8-47% over 3.9-14.4 years for overall mortality. Multivariate analyses showed that baseline steatosis and baseline fibrosis score were the most consistent predictors of fibrosis progression (significant in 6/21 and 5/21, studies, respectively) while baseline platelet count (significant in 6/13 studies), aspartate and alanine aminotransferase (AST/ALT) ratio, albumin, bilirubin, and age (each significant in 4/13 studies) were the most consistent predictors of clinical outcomes. Five studies developed predictive models but none were externally validated. Conclusions: Our review identified the variables that most consistently predict outcomes of patients with CHC allowing the application of risk based approaches to identify patients in need of early treatment and intensive monitoring. This approach maximizes effective use of resources and costly new direct-acting antiviral agents. Twit Text FOAVip Systematic review: Identifying patients with chronic hepatitis C in need of early treatment and intensive monitoring predictors and predictive models of disease progression ????Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25164152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25164152 #FOAvip English Wikipedia <ref>{{Cite pmid|25164152}}</ref> Systematic review: Identifying patients with chronic hepatitis C in need of early treatment and intensive monitoring predictors and predictive models of disease progression #MMPMID25164152 Konerman MA; Yapali S; Lok AS Aliment Pharmacol Ther 2014[Oct]; 40 (8): 863-79 PMID25164152show ga Background: Advances in hepatitis C therapies have led to increasing numbers of patients seeking treatment. As a result, logistical and financial concerns regarding how treatment can be provided to all patients with chronic hepatitis C (CHC) have emerged. Aim: The aim of this review was to evaluate predictors and predictive models of histologic progression and clinical outcomes for patients with CHC. Methods: MEDLINE via PubMed, EMBASE, Web of Science and Scopus were searched for studies published between January 2003 and June 2014.Two authors independently reviewed articles to select eligible studies and performed data abstraction. Results: Twenty-nine studies representing 5817 patients from 20 unique cohorts were included. The outcome incidence rates were widely variable: 16-61% during median follow-up of 2.5-10 years for fibrosis progression; 13-40% over 2.3-14.4 years for hepatic decompensation; and 8-47% over 3.9-14.4 years for overall mortality. Multivariate analyses showed that baseline steatosis and baseline fibrosis score were the most consistent predictors of fibrosis progression (significant in 6/21 and 5/21, studies, respectively) while baseline platelet count (significant in 6/13 studies), aspartate and alanine aminotransferase (AST/ALT) ratio, albumin, bilirubin, and age (each significant in 4/13 studies) were the most consistent predictors of clinical outcomes. Five studies developed predictive models but none were externally validated. Conclusions: Our review identified the variables that most consistently predict outcomes of patients with CHC allowing the application of risk based approaches to identify patients in need of early treatment and intensive monitoring. This approach maximizes effective use of resources and costly new direct-acting antiviral agents. äSystematic review: Identifying patients with chronic hepatitis C in ne(epmc).pdf DeepDyve Pubget Overpricing