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10.1016/j.cell.2014.04.030 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.04.030 C4167631!4167631!24906152     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 157 (6): 1353-63 Nephropedia Template TP {{tp|p=24906152|t=2014. The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing |pdf=|usr=}}{{24906152}} gab.com Text The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24906152 #FOAvip piRNAs guide an adaptive genome defense system that silences transposons during germline development. The Drosophila HP1 homolog Rhino is required for germline piRNA production. We show that Rhino binds specifically to the heterochromatic clusters that produce piRNA precursors, and that binding directly correlates with piRNA production. Rhino co-localizes to germline nuclear foci with Rai1/DXO related protein Cuff and the DEAD box protein UAP56, which are also required for germline piRNA production. RNA sequencing indicates that most cluster transcripts are not spliced, and that rhino, cuff and uap56 mutations increase expression of spliced cluster transcripts over 100 fold. LacI?Rhino fusion protein binding suppresses splicing of a reporter transgene, and is sufficient to trigger piRNA production from a trans combination of sense and antisense reporters. We therefore propose that Rhino anchors a nuclear complex that suppresses cluster transcript splicing, and speculate that stalled splicing differentiates piRNA precursors from mRNAs. Twit Text FOAVip The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24906152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24906152 #FOAvip English Wikipedia <ref>{{Cite pmid|24906152}}</ref> The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing #MMPMID24906152 Zhang Z; Wang J; Schultz N; Zhang F; Parhad SS; Tu S; Vreven T; Zamore PD; Weng Z; Theurkauf WE Cell 2014[Jun]; 157 (6): 1353-63 PMID24906152show ga piRNAs guide an adaptive genome defense system that silences transposons during germline development. The Drosophila HP1 homolog Rhino is required for germline piRNA production. We show that Rhino binds specifically to the heterochromatic clusters that produce piRNA precursors, and that binding directly correlates with piRNA production. Rhino co-localizes to germline nuclear foci with Rai1/DXO related protein Cuff and the DEAD box protein UAP56, which are also required for germline piRNA production. RNA sequencing indicates that most cluster transcripts are not spliced, and that rhino, cuff and uap56 mutations increase expression of spliced cluster transcripts over 100 fold. LacI?Rhino fusion protein binding suppresses splicing of a reporter transgene, and is sufficient to trigger piRNA production from a trans combination of sense and antisense reporters. We therefore propose that Rhino anchors a nuclear complex that suppresses cluster transcript splicing, and speculate that stalled splicing differentiates piRNA precursors from mRNAs. äThe HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA (epmc).pdf DeepDyve Pubget Overpricing