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10.1016/j.cell.2014.07.049

http://scihub22266oqcxt.onion/10.1016/j.cell.2014.07.049
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C4167378!4167378!25215491
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suck abstract from ncbi


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pmid25215491      Cell 2014 ; 158 (6): 1348-61
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  • Antagonistic Control of Social Behaviors by Inhibitory and Excitatory Neurons in the Medial Amygdala #MMPMID25215491
  • Hong W; Kim DW; Anderson DJ
  • Cell 2014[Sep]; 158 (6): 1348-61 PMID25215491show ga
  • Animals display a range of innate social behaviors that play essential roles in survival and reproduction. While the medial amygdala (MeA) has been implicated in prototypic social behaviors such as aggression, the circuit-level mechanisms controlling such behaviors are not well understood. Using cell-type specific functional manipulations, we find that distinct neuronal populations in the MeA control different social and asocial behaviors. A GABAergic subpopulation promotes aggression and two other social behaviors, while neighboring glutamatergic neurons promote repetitive self-grooming, an asocial behavior. Moreover, this glutamatergic subpopulation inhibits social interactions independently of its effect to promote self-grooming, while the GABAergic subpopulation inhibits self-grooming, even in a non-social context. These data suggest that social vs. repetitive asocial behaviors are controlled in an antagonistic manner by inhibitory vs. excitatory amygdala subpopulations, respectively. These findings provide a framework for understanding circuit-level mechanisms underlying opponency between innate behaviors, with implications for their perturbation in psychiatric disorders.
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